Bretylium or 6‐OHDA‐resistant, action potential‐evoked Ca2+ transients in varicosities of the mouse vas deferens
Action potential‐evoked calcium transients in varicosities in mouse vas deferens were monitored using laser scanning confocal microscopy. Their significance was examined by comparison with excitatory junction potentials (EJPs) and neurogenic contractions, both indirect measurements of transmitter re...
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| Published in: | British journal of pharmacology Vol. 135; no. 8; pp. 1845 - 1850 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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Oxford, UK
Blackwell Publishing Ltd
01-04-2002
Nature Publishing |
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| Abstract | Action potential‐evoked calcium transients in varicosities in mouse vas deferens were monitored using laser scanning confocal microscopy. Their significance was examined by comparison with excitatory junction potentials (EJPs) and neurogenic contractions, both indirect measurements of transmitter release. Bretylium abolished EJPs, as well as the ATP and NA‐mediated phases of contraction. However, bretylium revealed a prominent late component of contraction that was atropine‐sensitive. Bretylium abolished calcium transients in 21%, enhanced in 16% and had no effect in 63% of varicosities examined. Pre‐treatment with 6‐OHDA reduced NA levels to below detectable levels but many strings of varicosities still responded to nerve impulses with ‘normal’ calcium transients. Varicosities in which calcium transients were abolished by these agents were sympathetic. The identity of those varicosities in which calcium transients were resistant to bretylium (sympathetic but no uptake‐1 sites, parasympathetic, sensory) remains to be established.
British Journal of Pharmacology (2002) 135, 1845–1850; doi:10.1038/sj.bjp.0704677 |
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| AbstractList | Action potential‐evoked calcium transients in varicosities in mouse vas deferens were monitored using laser scanning confocal microscopy. Their significance was examined by comparison with excitatory junction potentials (EJPs) and neurogenic contractions, both indirect measurements of transmitter release. Bretylium abolished EJPs, as well as the ATP and NA‐mediated phases of contraction. However, bretylium revealed a prominent late component of contraction that was atropine‐sensitive. Bretylium abolished calcium transients in 21%, enhanced in 16% and had no effect in 63% of varicosities examined. Pre‐treatment with 6‐OHDA reduced NA levels to below detectable levels but many strings of varicosities still responded to nerve impulses with ‘normal’ calcium transients. Varicosities in which calcium transients were abolished by these agents were sympathetic. The identity of those varicosities in which calcium transients were resistant to bretylium (sympathetic but no uptake‐1 sites, parasympathetic, sensory) remains to be established.
British Journal of Pharmacology (2002) 135, 1845–1850; doi:10.1038/sj.bjp.0704677 Action potential-evoked calcium transients in varicosities in mouse vas deferens were monitored using laser scanning confocal microscopy. Their significance was examined by comparison with excitatory junction potentials (EJPs) and neurogenic contractions, both indirect measurements of transmitter release. Bretylium abolished EJPs, as well as the ATP and NA-mediated phases of contraction. However, bretylium revealed a prominent late component of contraction that was atropine-sensitive. Bretylium abolished calcium transients in 21%, enhanced in 16% and had no effect in 63% of varicosities examined. Pre-treatment with 6-OHDA reduced NA levels to below detectable levels but many strings of varicosities still responded to nerve impulses with 'normal' calcium transients. Varicosities in which calcium transients were abolished by these agents were sympathetic. The identity of those varicosities in which calcium transients were resistant to bretylium (sympathetic but no uptake-1 sites, parasympathetic, sensory) remains to be established. |
| Author | Cunnane, Tom C Jackson, V Margaret |
| AuthorAffiliation | 1 1 University Department of Pharmacology, Mansfield Road, Oxford, OX1 3QT |
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| Copyright | 2002 British Pharmacological Society 2002 INIST-CNRS Copyright Nature Publishing Group Apr 2002 Copyright 2002, Nature Publishing Group 2002 Nature Publishing Group |
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| DOI | 10.1038/sj.bjp.0704677 |
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| Keywords | Calcium Rodentia Electrophysiology Action potential Ionic current Antiarrhythmic agent Catecholamine Sympathetic nervous system In vitro Vas deferens Quaternary ammonium compound Electrodiagnosis Vertebrata Mammalia Mouse Autonomic nervous system Bretylium tosilate Animal Neurotransmitter Norepinephrine Excitatory postsynaptic potential ATP Urogenital system Parasympathetic nervous system |
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| References_xml | – volume: 404 start-page: 349 year: 1988 end-page: 364 article-title: Electrophysiological analysis of the inactivation of sympathetic transmitter in the guinea‐pig vas deferens publication-title: J. Physiol. – volume: 128 start-page: 1739 year: 1999 end-page: 1753 article-title: Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens publication-title: Br. J. Pharmacol. – volume: 50 start-page: 1 year: 1972 end-page: 24 article-title: Histochemical determination of neurotransmitter distribution publication-title: Res. Publ. Assoc. Res. Nerv. Ment. Dis. – volume: 502 start-page: 521 year: 1997 end-page: 536 article-title: Calcium in sympathetic varicosities of mouse vas deferens during facilitation, augmentation and autoinhibition publication-title: J. Physiol. – volume: 15 start-page: 265 year: 1960 end-page: 270 article-title: The selective accumulation of bretylium in sympathetic ganglia and their postganglionic nerves publication-title: Br. J. Pharmacol. – volume: 76 start-page: 39 year: 1989 end-page: 53 article-title: Noradrenergic, purinergic and cholinergic transmission in the mouse vas deferens: influence of field stimulation parameters, reserpinization, 6‐hydroxydopamine and 4‐aminopyridine publication-title: J. Neural. Transm. – volume: 89 start-page: 647 year: 1986 end-page: 659 article-title: Actions of α,β‐methylene ATP and 6‐hydroxydopamine on sympathetic neurotransmission in the vas deferens of the guinea‐pig, rat and mouse: support for co‐transmission publication-title: Br. J. Pharmacol. – volume: 83 start-page: 607 year: 1998 end-page: 616 article-title: Nitric oxide synthase is co‐localized with vasoactive intestinal polypeptide in postganglionic parasympathetic nerves innervating the rat vas deferens publication-title: Neuroscience – volume: 537 start-page: 3 year: 2001 end-page: 16 article-title: Characterisation of action potential‐evoked calcium transients in postganglionic sympathetic axon bundles publication-title: J. Physiol. – volume: 23 start-page: 275 year: 1987 end-page: 289 article-title: The mechanism of action of capsaicin on sensory C‐type neurons and their axons publication-title: Neuroscience – volume: 57 start-page: 887 year: 1993 end-page: 890 article-title: Intermittent release of noradrenaline by single pulses and release during short trains at high frequencies from sympathetic nerves in rat tail artery publication-title: Neuroscience – volume: 187 start-page: 51 year: 1966 end-page: 68 article-title: The uptake and release of radioactive noradrenaline by the splenic nerves of cats publication-title: J. Physiol. – volume: 399 start-page: 607 year: 1988a end-page: 632 article-title: Electrical activity at the sympathetic neuroeffector junction in the guinea‐pig vas deferens publication-title: J. Physiol. – volume: 171 start-page: 70 year: 1970 end-page: 79 article-title: Norepinephrine concentrating mechanisms in sympathetic nerve trunks publication-title: J. Pharmacol. Exp. Ther. – volume: 338 start-page: 504 year: 1988b end-page: 509 article-title: Studies on the mode of action of bretylium and guanethidine in post‐ganglionic sympathetic nerve fibres publication-title: Naunyn Schmiedebergs Arch. Pharmacol. – volume: 420 start-page: 211 year: 2000 end-page: 232 article-title: Immunolocalization of the Cocaine‐ and Antidepressant‐sensitive l‐Norepinephrine Transporter publication-title: J. Comp. Neuro. – volume: 435 start-page: 678 year: 1998 end-page: 686 article-title: Activity‐dependent intracellular Ca transients in unmyelinated nerve fibres of the isolated adult rat vagus publication-title: Pflügers Arch. |
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| Snippet | Action potential‐evoked calcium transients in varicosities in mouse vas deferens were monitored using laser scanning confocal microscopy. Their significance... Action potential-evoked calcium transients in varicosities in mouse vas deferens were monitored using laser scanning confocal microscopy. Their significance... |
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| SubjectTerms | 6‐OHDA Action Potentials - drug effects Action Potentials - physiology Adrenergic Agents - pharmacology Adrenergic Fibers - drug effects Adrenergic Fibers - physiology Animals Anti-Arrhythmia Agents - pharmacology Biological and medical sciences bretylium Bretylium Compounds - pharmacology Calcium - physiology calcium imaging Drug Resistance - physiology Fundamental and applied biological sciences. Psychology Male Mice Mice, Inbred BALB C mouse vas deferens Oxidopamine - pharmacology parasympathetic Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ sensory Special Report Sympathetic uptake‐1 Vas Deferens - drug effects Vas Deferens - innervation Vas Deferens - physiology Vertebrates: nervous system and sense organs |
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| Title | Bretylium or 6‐OHDA‐resistant, action potential‐evoked Ca2+ transients in varicosities of the mouse vas deferens |
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