Pathogenesis and immune response in tuberculous meningitis

Pathogenesis and immune response in tuberculous meningitis

Cerebral tuberculosis is the most severe type of extrapulmonary disease that is in developing countries highly predominant in children. Meningeal tuberculosis is the most common form and usually begins with respiratory infection followed by early haematogenous dissemination to extrapulmonary sites i...

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Bibliographic Details
Published in:The Malaysian journal of medical sciences Vol. 21; no. 1; pp. 4 - 10
Main Authors: Isabel, Bini Estela, Rogelio, Hernández Pando
Format: Journal Article
Language:English
Published: Malaysia Universiti Sains Malaysia Press 01-01-2014
Penerbit Universiti Sains Malaysia
Subjects:
Antigens
Blood-brain barrier
Chemotherapy
Disease
Immune system
Infections
Mycobacterium tuberculosis
Pathogenesis
Patients
Permeability
Review
Rodents
Studies
Tuberculosis
tuberculous meningitis
cerebrospinal fluid
tuberculosis
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Summary:Cerebral tuberculosis is the most severe type of extrapulmonary disease that is in developing countries highly predominant in children. Meningeal tuberculosis is the most common form and usually begins with respiratory infection followed by early haematogenous dissemination to extrapulmonary sites involving the brain. In comparison with the lung, Mycobacterium tuberculosis induces a very different immune response when infect the central nervous system. Herein, we review several aspects of the pathogenesis and immune response in pulmonary and cerebral tuberculosis in humans and experimental models and discuss the implications of this response in the cerebral infection outcome.
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ISSN:1394-195X
2180-4303