Analysis of SecA2‐dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector

Summary The pathogenicity of mycobacteria is closely associated with their ability to export virulence factors. For this purpose, mycobacteria possess different protein secretion systems, including the accessory Sec translocation pathway, SecA2. Although this pathway is associated with intracellular...

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Bibliographic Details
Published in:	Cellular microbiology Vol. 16; no. 2; pp. 280 - 295
Main Authors:	Woude, Aniek D., Stoop, Esther J. M., Stiess, Michael, Wang, Sen, Ummels, Roy, Stempvoort, Gunny, Piersma, Sander R., Cascioferro, Alessandro, Jiménez, Connie R., Houben, Edith N. G., Luirink, Joen, Pieters, Jean, Sar, Astrid M., Bitter, Wilbert
Format:	Journal Article
Language:	English
Published:	England Hindawi Limited 01-02-2014
Subjects:	Adenosine Triphosphatases - metabolism Animals Bacterial Proteins - metabolism Bacteriology Cyclic GMP-Dependent Protein Kinases - metabolism Danio rerio Disease Models, Animal DNA Transposable Elements Gene Knockout Techniques Immunoblotting Kinases Membrane Transport Proteins - metabolism Mutagenesis, Insertional Mycobacterium Mycobacterium Infections - microbiology Mycobacterium marinum Mycobacterium marinum - metabolism Mycobacterium marinum - pathogenicity Proteins Substrate Specificity Virulence Factors - metabolism Zebrafish
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