New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2

• Published in: Marine drugs Vol. 20; no. 1; p. 77
• Main Authors: Girich, Elena V, Rasin, Anton B, Popov, Roman S, Yurchenko, Ekaterina A, Chingizova, Ekaterina A, Trinh, Phan Thi Hoai, Ngoc, Ngo Thi Duy, Pivkin, Mikhail V, Zhuravleva, Olesya I, Yurchenko, Anton N
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17-01-2022; MDPI
• Subjects: Amino acids; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Aquatic Organisms; Aspergillus; Aspergillus terreus; Cancer; Cell Line, Tumor; Cell lines; Cinnamic acid; Cytotoxicity; Enzymes; Fungi; Genes; Humans; Magnoliopsida; Mangroves; Metabolites; Microbial Sensitivity Tests; NMR; Nuclear magnetic resonance; Peptides; Peptides - chemistry; Peptides - pharmacology; Sortase; Staphylococcus aureus - drug effects; Toxicity; Tumor cell lines; diketopiperazines; marine-derived fungi; secondary metabolites; sortase A; cinnamic acid; mangrove-derived fungi; tripeptide derivatives; cytotoxicity
• ISSN: 1660-3397
• DOI: 10.3390/md20010077

Three new tripeptide derivatives asterripeptides A-C (
-
) were isolated from Vietnamese mangrove-derived fungus
LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of all stereocenters were determined using the Murfey's method. The isolated compounds
-
contain a rare fungi cinnamic acid residue. The cytotoxicity of isolated compounds against several cancer cell lines and inhibition ability of sortase A from
of asterripeptides A-C were investigated.