Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice

Mechanical ventilation with O₂-rich gas (MV-O₂) offers life-saving treatment for respiratory failure, but also promotes lung injury. We previously reported that MV-O2 of newborn mice increased lung elastase activity, causing elastin degradation and redistribution of elastic fibers from septal tips t...

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 184; no. 5; pp. 537 - 546
Main Authors:	Hilgendorff, Anne, Parai, Kakoli, Ertsey, Robert, Jain, Noopur, Navarro, Edwin F, Peterson, Joanna L, Tamosiuniene, Rasa, Nicolls, Mark R, Starcher, Barry C, Rabinovitch, Marlene, Bland, Richard D
Format:	Journal Article
Language:	English
Published:	United States American Thoracic Society 01-09-2011
Subjects:	Animals Animals, Newborn Apoptosis Disease Models, Animal Elafin - pharmacology Lung - drug effects Lung - enzymology Lung - growth & development Mice Organogenesis - drug effects Pancreatic Elastase - antagonists & inhibitors Pancreatic Elastase - metabolism Protease Inhibitors - pharmacology Respiration, Artificial Respiratory Insufficiency - enzymology Respiratory Insufficiency - physiopathology Respiratory Insufficiency - therapy
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