Response of intraventricular macrophages after a penetrant cerebral lesion

• Published in: Journal of anatomy Vol. 160; pp. 145 - 155
• Main Authors: MAXWELL, W. L, MCGADEY, J
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01-10-1988
• Subjects: Animals; Biological and medical sciences; Cerebral Ventricles - injuries; Choroid Plexus - ultrastructure; Ependyma - ultrastructure; Macrophages - physiology; Macrophages - ultrastructure; Medical sciences; Microscopy, Electron, Scanning; Nervous system involvement in other diseases. Miscellaneous; Neurology; Rats; Rats, Inbred Strains; Wounds, Penetrating - physiopathology; Brain; Scanning electron microscopy; Nervous system diseases; Rat; Rodentia; Central nervous system; Blood; Vertebrata; Blood cell; Mammalia; Animal; Lesion; Macrophage
• ISSN: 0021-8782; 1469-7580

The response of epiplexus and supraependymal cells to extravasated blood after a penetrant cerebral lesion was investigated. Epiplexus cells respond more actively than supraependymal cells. The epiplexus cells tend to aggregate near areas of extravasation of erythrocytes, this being most marked 6 hours after injury. Epiplexus cells lose their smooth surface appearance, retract their filopodia and adopt a more spherical form, with short microvilli or blebs. Numerous inclusion vesicles develop; some contain disrupted erythrocytes 6-12 hours after injury and these are still present 24-30 hours after injury. By 8-16 days after injury epiplexus cells resume a smooth surface appearance and the number of inclusion vesicles is much reduced. This suggests reversion to a quiescent state, from an earlier active state.