Steroid secretion by a virilizing lipoid cell ovarian tumor: origins of dehydroepiandrosterone sulfate

A 78-year-old woman had a 3-year history of severe virilization caused by a lipoid cell ovarian tumor localized by pelvic ultrasound examination and NP-59 scan. Steroid secretion was evaluated by the following: 1) peripheral plasma levels before and after hormonal stimulation with ACTH or hCG, 2) ve...

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Bibliographic Details
Published in:	Obstetrics and gynecology (New York. 1953) Vol. 74; no. 3 Pt 2; p. 502
Main Authors:	Shenker, Y, Malozowski, S N, Ayers, J, Grekin, R J, Barkan, A L
Format:	Journal Article
Language:	English
Published:	United States 01-09-1989
Subjects:	Aged Androgens - secretion Dehydroepiandrosterone - analogs & derivatives Dehydroepiandrosterone - secretion Dehydroepiandrosterone Sulfate Female Humans Ovarian Neoplasms - secretion Ovary - secretion Testosterone - secretion Virilism - etiology
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Summary:	A 78-year-old woman had a 3-year history of severe virilization caused by a lipoid cell ovarian tumor localized by pelvic ultrasound examination and NP-59 scan. Steroid secretion was evaluated by the following: 1) peripheral plasma levels before and after hormonal stimulation with ACTH or hCG, 2) venous catheterization and measurement of steroid levels in the left and right ovarian veins during surgery, 3) measurements of enzymatic activities in the tumor tissue compared with those in normal ovarian tissue, and 4) steroid secretion studies in vitro of the tumor tissue, surrounding tissue, and contralateral ovarian tissue. The tumor tissue secreted both delta 5 and delta 4 androgens, including dehydroepiandrosterone sulfate. Dehydroepiandrosterone sulfate was also secreted by the surrounding and contralateral ovarian tissue.
ISSN:	0029-7844