Acute uric acid nephropathy in pregnancy

Although uric acid clearance increases during gestation, uric acid nephropathy is a rare cause of acute renal failure in the pregnant woman. A 38-year-old woman experienced acute renal failure due to acute uric acid nephropathy at 30 weeks' gestation. The diagnosis was based on extreme hyperuri...

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Bibliographic Details
Published in:	Obstetrics and gynecology (New York. 1953) Vol. 80; no. 3 Pt 2; p. 488
Main Authors:	Alexopoulos, E, Tampakoudis, P, Bili, H, Mantalenakis, S
Format:	Journal Article
Language:	English
Published:	United States 01-09-1992
Subjects:	Acute Kidney Injury - epidemiology Acute Kidney Injury - etiology Adult Female Humans Maternal Age Pregnancy Pregnancy Complications - epidemiology Pregnancy Complications - etiology Pregnancy, High-Risk Uric Acid - metabolism
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Summary:	Although uric acid clearance increases during gestation, uric acid nephropathy is a rare cause of acute renal failure in the pregnant woman. A 38-year-old woman experienced acute renal failure due to acute uric acid nephropathy at 30 weeks' gestation. The diagnosis was based on extreme hyperuricemia and an elevated uric acid-creatinine ratio. Treatment with forced diuresis, urine alkalinization, and mannitol infusion resulted in a prompt and complete recovery of renal function. The woman ultimately gave birth to a healthy child. Acute uric acid nephropathy during pregnancy responds to conventional medical therapy.
ISSN:	0029-7844