Up-regulation of fibroblast growth factor-binding protein, by β-catenin during colon carcinogenesis

• Published in: Cancer research (Chicago, Ill.) Vol. 63; no. 23; pp. 8085 - 8089
• Main Authors: RAY, Ranjan, CABAL-MANZANO, Rafael, MOSER, Amy R, WALDMAN, Todd, ZIPPER, Laurie M, AIGNER, Achim, BYERS, Stephen W, RIEGEL, Anna T, WELLSTEIN, Anton
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01-12-2003
• Subjects: Adenoma - genetics; Adenoma - metabolism; Animals; Antineoplastic agents; beta Catenin; Biological and medical sciences; Carrier Proteins - biosynthesis; Carrier Proteins - genetics; Colonic Neoplasms - genetics; Colonic Neoplasms - metabolism; Cytoskeletal Proteins - biosynthesis; Cytoskeletal Proteins - genetics; Cytoskeletal Proteins - physiology; Gene Expression Regulation, Neoplastic - drug effects; Humans; Intercellular Signaling Peptides and Proteins; Lithium Chloride - pharmacology; Medical sciences; Mice; Mice, Inbred C57BL; Pharmacology. Drug treatments; Promoter Regions, Genetic; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Trans-Activators - biosynthesis; Trans-Activators - genetics; Trans-Activators - physiology; Transfection; Tumors; Up-Regulation - drug effects; Fibroblast growth factor; Binding protein; Regulation(control); Digestive system; Gut; Colon; Carcinogenesis; Catenin
• ISSN: 0008-5472; 1538-7445

Fibroblast growth factor-binding protein (FGF-BP) releases immobilized FGFs from the extracellular matrix and can function as an angiogenic switch molecule in cancer. Here we show that FGF-BP is up-regulated in early dysplastic lesions of the human colon that are typically associated with a loss of adenomatous polyposis coli and up-regulation of beta-catenin. In addition, FGF-BP expression is induced in dysplastic lesions in ApcMin/+ mice in parallel with the up-regulation of beta-catenin. Also, in cell culture studies FGF-BP is induced by beta-catenin through direct activation of the FGF-BP gene promoter. We conclude that FGF-BP is a target gene of beta-catenin.