Cyclosporine-induced autologous graft-versus-host disease following autologous blood stem cell transplantation for lymphoma

Eight consecutive patients with relapsed/refractory non-Hodgkin's lymphoma or Hodgkin's disease received conditioning therapy with BCNU, etoposide, cytosine arabinoside and melphalan (BEAM) followed by autologous blood stem cell transplantation (ABSCT). Cyclosporine was administered from d...

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Bibliographic Details
Published in:	Bone marrow transplantation (Basingstoke) Vol. 17; no. 6; p. 1081
Main Authors:	Pati, A R, Godder, K T, Abhyankar, S H, Gee, A P, Henslee-Downey, P J
Format:	Journal Article
Language:	English
Published:	England 01-06-1996
Subjects:	Adult Cyclosporine - pharmacology Female Graft vs Host Disease - chemically induced Hematopoietic Stem Cell Transplantation Humans Immunosuppressive Agents - pharmacology Lymphoma - therapy Male Middle Aged Transplantation, Autologous
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Summary:	Eight consecutive patients with relapsed/refractory non-Hodgkin's lymphoma or Hodgkin's disease received conditioning therapy with BCNU, etoposide, cytosine arabinoside and melphalan (BEAM) followed by autologous blood stem cell transplantation (ABSCT). Cyclosporine was administered from day +1 until day +28 post-ABSCT to induce autologous graft-versus-host disease (GVHD) for a possible antitumor effect. Three patients developed histologically documented grade II GVHD between 22-40 days post-transplant. GVHD resolved with local hydrocortisone 1% application in one patient and after a short course of steroid in the remaining two patients. Further studies are required to document any beneficial antitumor effect of such therapy following ABSCT.
ISSN:	0268-3369