Translational Neuroscience in Autism: From Neuropathology to Transcranial Magnetic Stimulation Therapies

The presence of heterotopias, increased regional density of neurons at the gray-white matter junction, and focal cortical dysplasias all suggest an abnormality of neuronal migration in autism spectrum disorder (ASD). The abnormality is borne from a dissonance in timing between radial and tangentiall...

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Bibliographic Details
Published in:	The Psychiatric clinics of North America Vol. 43; no. 2; pp. 229 - 248
Main Authors:	Casanova, Manuel F, Sokhadze, Estate M, Casanova, Emily L, Opris, Ioan, Abujadi, Caio, Marcolin, Marco Antonio, Li, Xiaoli
Format:	Journal Article
Language:	English
Published:	United States 01-06-2020
Subjects:	Autism Spectrum Disorder - pathology Autism Spectrum Disorder - therapy Brain - pathology Child Executive Function Humans Transcranial Magnetic Stimulation Minicolumns Executive function Transcranial magnetic stimulation Gamma oscillations Autism spectrum disorder
Online Access:	Get full text
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Summary:	The presence of heterotopias, increased regional density of neurons at the gray-white matter junction, and focal cortical dysplasias all suggest an abnormality of neuronal migration in autism spectrum disorder (ASD). The abnormality is borne from a dissonance in timing between radial and tangentially migrating neuroblasts to the developing cortical plate. The uncoupling of excitatory and inhibitory cortical cells disturbs the coordinated interactions of neurons within local networks, thus providing abnormal patterns of brainwave activity in the gamma bandwidth. In ASD, gamma oscillation abnormalities and autonomic markers offer measures of therapeutic progress and help in the identification of subgroups.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2
ISSN:	0193-953X 1558-3147
DOI:	10.1016/j.psc.2020.02.004