Novel Twin‐Crystal Nanosheets with MnO2 Modification to Combat Bacterial Biofilm against Periodontal Infections via Multipattern Strategies

• Published in: Advanced healthcare materials Vol. 12; no. 19; pp. e2300313 - n/a
• Main Authors: Chen, Qiuhan, Qi, Manlin, Shi, Fangyu, Liu, Chengyu, Shi, Yujia, Sun, Yue, Bai, Xue, Wang, Lin, Sun, Xiaolin, Dong, Biao, Li, Chunyan
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01-07-2023
• Subjects: Aerobic bacteria; Anaerobic microorganisms; antibacterials; Bacteria; Bacterial infections; Biofilms; chemodynamical therapy; Copper sulfides; Dissipation; Functional integration; Gum disease; Hydrogen peroxide; Hydroxyl radicals; Infections; Manganese dioxide; Nanocomposites; Nanosheets; periodontal disease; Periodontitis; Photothermal conversion; photothermal therapy; Single crystals; twin crystals
• ISSN: 2192-2640; 2192-2659
• DOI: 10.1002/adhm.202300313

Nowadays the multifunctional approaches to kill oral bacteria based on various nanocomposites have made great progress against periodontal infections, while the material structure and its functional integration are still insufficient. Herein, this work proposes a therapeutic strategy of chemodynamical therapy (CDT) and photothermal therapy (PTT) in monocrystals to effectively enhance the synergistic treatment. The CuS/MnS@MnO2 consisting of hexagonal CuS/MnS nano‐twin‐crystal with a shell layer of MnO2 is developed. In this nanosystem, the purpose of synergistic treatment of periodontitis by combining PTT/CDT is achieved within a CuS/MnS monocrystal, where CuS serves to achieve photothermal conversion, dissipate the biofilm and transfer the heat in situ to the integrated MnS, thus promoting the Mn2+‐mediated CDT process. Meanwhile, the CDT process can generate the highly toxic hydroxyl radical to destroy extracellular DNA by utilization of endogenous H2O2 produced by Streptococci in the oral biofilm, cooperating with PTT to dissipate the bacterial biofilm. With the design of the outer shell of MnO2, the selective bacteria‐killing can be realized by producing oxygen which can protect the periodontal non‐pathogenic aerobic bacteria and threaten the survival of anaerobic pathogens. Therefore, such design via multipattern strategies to combat microorganisms would provide a bright prospect for the clinical treatment of bacterial infections.
This work provides antibacterial CuS/MnS@MnO2 nanocomposites of multipattern strategies, which can be directly excited by near‐infrared (NIR, 808 nm) to achieve the synergistic effects of PTT/CDT/O2. Triggered by NIR, CDT is enhanced effectively by heat transfer in situ, which can destroy bacterial biofilm and kill pathogenic bacteria by photothermal effect and hydroxyl radical. The O2 produced alleviates the anoxic microenvironment to reverse periodontitis.