VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP

Fluctuations in oxygen are associated with the development of severe retinopathy of prematurity (ROP) in humans. However, the causal relationships between oxygen variability and severe ROP remain unknown. We investigated whether isoforms of vascular endothelial growth factor (VEGF) were differential...

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Bibliographic Details
Published in:	Molecular vision Vol. 10; pp. 512 - 520
Main Authors:	McColm, Janet R, Geisen, Pete, Hartnett, M Elizabeth
Format:	Journal Article
Language:	English
Published:	United States 21-07-2004
Subjects:	Animals Animals, Newborn Enzyme-Linked Immunosorbent Assay Eye Proteins Female Fluorescent Antibody Technique, Indirect Gene Expression Regulation - physiology Humans Hyperoxia - metabolism Hypoxia - metabolism Infant, Newborn Neovascularization, Pathologic - metabolism Nerve Growth Factors Oxygen - toxicity Pregnancy Protein Isoforms - genetics Protein Isoforms - metabolism Proteins - metabolism Rats Rats, Sprague-Dawley Retinopathy of Prematurity - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Serpins - metabolism Up-Regulation Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vitreous Body - blood supply
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