Immune-complex deposits in "pauci-immune" glomerulonephritis: a case report and brief review of recent literature

Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is considered a "pauci-immune" disease, characterized by absent or mild glomerular tuft staining for immunoglobulin and/or complement. We describe a 72-year-old man with progressive renal failure over five months who...

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Published in:	Archives of medical science Vol. 6; no. 4; pp. 633 - 637
Main Authors:	El-Ters, Mireille, Muthyala, Umadevi, Philipneri, Marie D, Hussein, Fadi A, Lentine, Krista L
Format:	Journal Article
Language:	English
Published:	Poland Termedia Publishing House 30-08-2010
Subjects:	Case Report glomerulonephritis anti-neutrophil cytoplasmic antibodies immune deposits
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Abstract	Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is considered a "pauci-immune" disease, characterized by absent or mild glomerular tuft staining for immunoglobulin and/or complement. We describe a 72-year-old man with progressive renal failure over five months who was found to have P-ANCA associated crescentic glomerulonephritis. Renal biopsy also revealed immunofluorescence staining for Immunoglobulin G and C3. Treatment comprised corticosteroids, cyclophosphamide, and plasmapheresis but unfortunately kidney function did not recover, likely due to substantial interstitial fibrosis at diagnosis. This case illustrates that serologic evaluation for ANCAs should not be discounted when immune deposits are present. Prompt diagnosis is warranted.
AbstractList	Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is considered a "pauci-immune" disease, characterized by absent or mild glomerular tuft staining for immunoglobulin and/or complement. We describe a 72-year-old man with progressive renal failure over five months who was found to have P-ANCA associated crescentic glomerulonephritis. Renal biopsy also revealed immunofluorescence staining for Immunoglobulin G and C3. Treatment comprised corticosteroids, cyclophosphamide, and plasmapheresis but unfortunately kidney function did not recover, likely due to substantial interstitial fibrosis at diagnosis. This case illustrates that serologic evaluation for ANCAs should not be discounted when immune deposits are present. Prompt diagnosis is warranted.
Author	Hussein, Fadi A El-Ters, Mireille Muthyala, Umadevi Philipneri, Marie D Lentine, Krista L
AuthorAffiliation	2 Division of Endocrinology, Saint Louis University of Medicine, St Louis, USA 3 Division of Nephrology, Saint Louis University School of Medicine, St. Louis, USA 4 Center for Outcomes Research, Saint Louis University, St. Louis, USA 1 Department Internal Medicine, Saint Louis University School of Medicine, St. Louis, USA
AuthorAffiliation_xml	– name: 1 Department Internal Medicine, Saint Louis University School of Medicine, St. Louis, USA – name: 4 Center for Outcomes Research, Saint Louis University, St. Louis, USA – name: 2 Division of Endocrinology, Saint Louis University of Medicine, St Louis, USA – name: 3 Division of Nephrology, Saint Louis University School of Medicine, St. Louis, USA
Author_xml	– sequence: 1 givenname: Mireille surname: El-Ters fullname: El-Ters, Mireille organization: Department Internal Medicine, Saint Louis University School of Medicine, St. Louis, USA – sequence: 2 givenname: Umadevi surname: Muthyala fullname: Muthyala, Umadevi – sequence: 3 givenname: Marie D surname: Philipneri fullname: Philipneri, Marie D – sequence: 4 givenname: Fadi A surname: Hussein fullname: Hussein, Fadi A – sequence: 5 givenname: Krista L surname: Lentine fullname: Lentine, Krista L
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22371811$$D View this record in MEDLINE/PubMed
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Title	Immune-complex deposits in "pauci-immune" glomerulonephritis: a case report and brief review of recent literature
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