Diagnostic value of sonazoid for hepatic metastasis: comparison with FDG PET/CT

• Published in: Hepato-gastroenterology Vol. 57; no. 102-103; p. 1237
• Main Authors: Hiraoka, Atsushi, Kume, Misaki, Miyagawa, Masao, Tazuya, Nayu, Ichiryu, Misa, Ochi, Hironori, Tanabe, Atsushi, Nakahara, Hiromasa, Shinbata, Yuki, Kan, Miki, Doi, Shigekazu, Hidaka, Satoshi, Uehara, Takahide, Tanihira, Tetsuya, Hasebe, Aki, Miyamoto, Yasunao, Ninomiya, Tomoyuki, Hirooka, Masashi, Abe, Masanori, Hiasa, Yoichi, Matsuura, Bunzo, Onji, Morikazu, Michitaka, Kojiro
• Format: Journal Article
• Language: English
• Published: Greece 01-09-2010
• Subjects: Aged; Contrast Media; Ferric Compounds; Fluorodeoxyglucose F18; Humans; Image Enhancement; Iron; Liver Neoplasms - diagnosis; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - secondary; Middle Aged; Oxides; Positron-Emission Tomography; Tomography, X-Ray Computed; Ultrasonography
• ISSN: 0172-6390

This study was conducted to evaluate the diagnostic efficacy of contrast enhanced ultrasonography (CEUS) with perflubutane (Sonazoid) for hepatic metastasis and compared it with that of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) computed tomography (CT).
From January 2007 to July 2009, 109 Japanese patients with gastrointestinal tract cancer were enrolled, of whom 4 had esophageal cancer, 28 gastric cancer, 1 duodenal cancer, and 76 colorectal cancer. After a bolus injection with Sonazoid (0.5 ml/body), the liver was scanned in both arterial and Kupffer phases. The results of PET/CT and other abdominal imaging examinations were not shown to the CEUS operators. We compared diagnostic efficacy between CEUS and PET/CT.
Average values for age, body mass index, and maximum diameter of the hepatic metastasis were 68.7 +/- 11.0 years, 21.2 +/- 4.2, and 29.2 +/- 20.5mm, respectively. Hepatic metastasis were suspected in 31 patients based on PET/CT findings and 32 by CEUS. Finally, hepatic metastasis was diagnosed in 30 patients. The sensitivity, specificity, and accuracy rates for CEUS and PET/CT were similar (100% vs. 100%, 97.5% vs. 98.7%, and 95.5% vs. 93.6%, respectively).
CEUS had a diagnostic value similar to that of PET/CT for hepatic metastasis.