Sublingual and oral morphine administration. Review and new findings

Clinical reports rave about the efficacy of sublingual morphine, but most research data suggest that sublingual morphine lacks the necessary physical characteristics to be absorbed through sublingual tissues. This article clarifies these assertions by reviewing the clinical literature that supports...

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Bibliographic Details
Published in:	The Nursing clinics of North America Vol. 30; no. 4; p. 725
Main Authors:	Robison, J M, Wilkie, D J, Campbell, B
Format:	Journal Article
Language:	English
Published:	United States 01-12-1995
Subjects:	Absorption Administration, Oral Administration, Sublingual Analgesics, Opioid - blood Analgesics, Opioid - therapeutic use Biological Availability Humans Morphine - administration & dosage Morphine - blood Morphine - therapeutic use Neoplasms - physiopathology Pain - blood Pain - drug therapy Pain - etiology Time Factors
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Summary:	Clinical reports rave about the efficacy of sublingual morphine, but most research data suggest that sublingual morphine lacks the necessary physical characteristics to be absorbed through sublingual tissues. This article clarifies these assertions by reviewing the clinical literature that supports sublingual administration, the theories relevant to sublingual morphine administration, and the pharmacokinetic research that supports or negates the benefit of this route. Recommendations for clinical nursing practice are provided to guide decision-making in care of patients with cancer pain.
ISSN:	0029-6465