Alternative design of a tRNA core for aminoacylation

The core of Escherichia coli tRNA(Cys) is important for aminoacylation of the tRNA by cysteine-tRNA synthetase. This core differs from the common tRNA core by having a G15:G48, rather than a G15:C48 base-pair. Substitution of G15:G48 with G15:C48 decreases the catalytic efficiency of aminoacylation...

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Bibliographic Details
Published in:	Journal of molecular biology Vol. 303; no. 4; pp. 503 - 514
Main Authors:	Christian, T, Lipman, R S, Evilia, C, Hou, Y M
Format:	Journal Article
Language:	English
Published:	England 03-11-2000
Subjects:	Acylation Amino Acyl-tRNA Synthetases - metabolism Anticodon - genetics Base Pairing - genetics Base Sequence Escherichia coli - enzymology Escherichia coli - genetics Kinetics Models, Molecular Molecular Sequence Data Mutation - genetics Nucleic Acid Conformation RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Transfer, Cys - chemistry RNA, Transfer, Cys - genetics RNA, Transfer, Cys - metabolism RNA, Transfer, Gln - chemistry RNA, Transfer, Gln - genetics Substrate Specificity Sulfuric Acid Esters - metabolism Thermodynamics
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