Anticancer activity of new 3-amino-pyrrolidinedione-nitrogen mustard derivatives on murine sarcoma 180

A 2,5-pyrrolidinedione linked nitrogen mustard derivative, (R,S)3-[N,N-bis(2-chloroethyl)]-amino-1-(2'-methoxyphenyl)pyrrolidine- 2,5-dione hydrochloride (I) showed a marked antiproliferative effect on mouse Sarcoma 180. Since (I) is also active against L1210 and P388 leukaemias, its toxicity i...

Full description

Saved in:

Bibliographic Details
Published in:	Anticancer research Vol. 7; no. 1; p. 87
Main Authors:	Naik, S D, Ambaye, R Y, Gokhale, S V
Format:	Journal Article
Language:	English
Published:	Greece 01-01-1987
Subjects:	Animals Chemical and Drug Induced Liver Injury Mice Necrosis - pathology Nitrogen Mustard Compounds - therapeutic use Nitrogen Mustard Compounds - toxicity Pyrrolidinones - therapeutic use Pyrrolidinones - toxicity Sarcoma 180 - drug therapy
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A 2,5-pyrrolidinedione linked nitrogen mustard derivative, (R,S)3-[N,N-bis(2-chloroethyl)]-amino-1-(2'-methoxyphenyl)pyrrolidine- 2,5-dione hydrochloride (I) showed a marked antiproliferative effect on mouse Sarcoma 180. Since (I) is also active against L1210 and P388 leukaemias, its toxicity in mice was evaluated. A study of acute toxicity revealed focal liver cell necrosis. Another derivative, (R,S)3-[N,N-bis-(2-chloroethyl)]amino-1-(4'-n-butoxyphenyl)pyrrolidine- 2,5-dione dihydrate (II), which also possessed significant anticancer effect on P388 and L1210 leukaemias, was inactive against Sarcoma 180.
ISSN:	0250-7005