Antifungal chemoprophylaxis in cancer children: a prospective randomized controlled study

We report a prospective, randomized, controlled study of antifungal chemoprophylaxis in forty immunocompromised children with hematologic malignancies, receiving respectively itraconazole, ketoconazole, amphotericin-B and no prophylaxis. Fungal isolates from patients' saliva or stools were obta...

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Bibliographic Details
Published in:	Microbiologica Vol. 13; no. 4; p. 347
Main Authors:	Caselli, D, Aricò, M, Michelone, G, Cavanna, C, Nespoli, L, Burgio, G R
Format:	Journal Article
Language:	English
Published:	Italy 01-10-1990
Subjects:	Adolescent Amphotericin B - therapeutic use Antifungal Agents - therapeutic use Child Child, Preschool Feces - microbiology Female Humans Infant Itraconazole Ketoconazole - analogs & derivatives Ketoconazole - therapeutic use Male Mycoses - prevention & control Neoplasms - drug therapy Pharynx - microbiology Prospective Studies
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Summary:	We report a prospective, randomized, controlled study of antifungal chemoprophylaxis in forty immunocompromised children with hematologic malignancies, receiving respectively itraconazole, ketoconazole, amphotericin-B and no prophylaxis. Fungal isolates from patients' saliva or stools were obtained from 19/40 patients (Candida albicans from 15 patients). Disseminated infection was never observed. Fungal isolates were significantly less frequent in the ketoconazole group of patients vs any other group. Systemic antifungal chemoprophylaxis with ketoconazole appears more effective even than the recently introduced itraconazole.
ISSN:	0391-5352