Urate-oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia, treated in the Société Française d'Oncologie Pédiatrique LMB89 protocol

• Published in: Annals of oncology Vol. 13; no. 5; pp. 789 - 795
• Main Authors: PATTE, C, SAKIROGLU, C, ANSOBORLO, S, BARUCHEL, A, PLOUVIER, E, PACQUEMENT, H, BABIN-BOILLETOT, A
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-05-2002
• Subjects: Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Biological and medical sciences; Cyclophosphamide - administration & dosage; Cyclophosphamide - adverse effects; Cytarabine - administration & dosage; Cytarabine - adverse effects; Doxorubicin - administration & dosage; Doxorubicin - adverse effects; Drug toxicity and drugs side effects treatment; Etoposide - administration & dosage; Etoposide - adverse effects; Female; France; Humans; Hydrocortisone - administration & dosage; Hydrocortisone - adverse effects; Leucovorin - administration & dosage; Leucovorin - adverse effects; Lymphoma, B-Cell - drug therapy; Lymphoma, B-Cell - mortality; Lymphoma, B-Cell - pathology; Male; Medical sciences; Methotrexate - administration & dosage; Methotrexate - adverse effects; Neoplasm Staging; Pharmacology. Drug treatments; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; Prednisone - administration & dosage; Prednisone - adverse effects; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Survival Rate; Toxicity: urogenital system; Treatment Outcome; Tumor Lysis Syndrome - drug therapy; Tumor Lysis Syndrome - etiology; Tumor Lysis Syndrome - mortality; Urate Oxidase - administration & dosage; Urate Oxidase - adverse effects; Vincristine - administration & dosage; Vincristine - adverse effects; France; Antineoplastic agent; Hydroelectrolytic balance disorder; Toxicity; Urate oxidase; Leukemia; Inorganic element; Prevention; Lymphoproliferative syndrome; Complication; Advanced stage; Hypocalcemia; Creatinine; Human; Drug combination; Enzyme; Treatment efficiency; Malignant hemopathy; B-Lymphocyte; Non Hodgkin lymphoma; Metabolic disorder; Chemotherapy; Treatment; Hyperphosphatemia; Dialysis; Oxidoreductases; Tumor lysis syndrome
• ISSN: 0923-7534; 1569-8041
• DOI: 10.1093/annonc/mdf134

To evaluate the frequency of metabolic complications and dialysis due to tumor lysis syndrome in patients with B-cell advanced-stage non-Hodgkin's lymphoma (NHL) and L3 leukemia at initiation of chemotherapy including the use of urate-oxidase.
Retrospective review of the clinical records of 410 patients with stage III and IV B-cell NHL and L3 leukemia treated in France and prospectively registered in the LMB89 protocol.
During the first week of chemotherapy, only 34 of 410 patients recorded metabolic problems that included hypocalcemia (< 70 mg/dl) in 24 patients, hyperphosphatemia (> 6.5 mg/dl) in 28 and elevation of creatinine > or = 2 SD in 16. Six patients underwent dialysis for life-threatening problems and a seventh as a preventive measure. In the other 27 cases, metabolic problems were successfully resolved using urate-oxidase in combination with alkaline hyperhydration. Among the 410 patients, one case of hemolysis was reported and there was no severe allergic reaction to urate-oxidase.
Only 1.7% of patients in our study receiving urate-oxidase during their induction chemotherapy needed renal dialysis. Urate-oxidase was well tolerated, and used as prophylaxis and/or treatment of hyperuricemia and tumor lysis syndrome consistently gave a lower rate of renal and metabolic complications than in other series of similar patients.