Experimental induction of Proteus mirabilis cystitis in the pony and evaluation of therapy with trimethoprim-sulfadiazine

Proteus mirabilis cystitis was induced in 9 ponies by chemically eroding the bladder mucosa before the organism was inoculated. Comparisons were made in the treatment of P mirabilis cystitis between ponies treated daily for 13 days with a trimethoprim-sulfadiazine (TMP-SDZ) paste and both positive a...

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Bibliographic Details
Published in:	American journal of veterinary research Vol. 42; no. 7; p. 1203
Main Authors:	Divers, T J, Byars, T D, Murch, O, Sigel, C W
Format:	Journal Article
Language:	English
Published:	United States 01-01-1981
Subjects:	Administration, Oral Animals Cystitis - drug therapy Cystitis - veterinary Drug Combinations Female Horse Diseases - drug therapy Horses Nitrofurantoin - therapeutic use Proteus Infections - drug therapy Proteus Infections - veterinary Proteus mirabilis Sulfadiazine - therapeutic use Trimethoprim - therapeutic use
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Summary:	Proteus mirabilis cystitis was induced in 9 ponies by chemically eroding the bladder mucosa before the organism was inoculated. Comparisons were made in the treatment of P mirabilis cystitis between ponies treated daily for 13 days with a trimethoprim-sulfadiazine (TMP-SDZ) paste and both positive and negative controls. Urine cultures from ponies treated with TMP-SDZ became negative for P mirabilis between days 3 and 9 after the start of the treatment, whereas positive controls remained infected until day 13. Urine cultures from all ponies were negative for P mirabilis on day 28. Urine concentrations of TMP and SDZ were relatively high after day 1 of therapy.
ISSN:	0002-9645