Antibody responses in vivo in chromosome instability syndromes with immunodeficiency

• Published in: Clinical and experimental immunology Vol. 57; no. 3; pp. 529 - 534
• Main Authors: WEEMAES, C. M. R, THE, T. H, VAN MUNSTER, P. J. J, BAKKEREN, J. A. J. M
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01-09-1984
• Subjects: Adolescent; Ataxia Telangiectasia - immunology; Biological and medical sciences; Bloom Syndrome - immunology; Child; Child, Preschool; Chromosome Aberrations - immunology; Chromosome Disorders; Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...); Diphtheria Toxoid - immunology; Female; Hemocyanins - pharmacology; Humans; Immunoglobulin A - biosynthesis; Immunoglobulin G - biosynthesis; Immunoglobulin M - biosynthesis; Immunologic Memory; Male; Medical genetics; Medical sciences; Poliovirus Vaccine, Inactivated - immunology; Tetanus Toxoid - immunology; Human; Immunopathology; In vivo; Bloom syndrome; Immune response; Ataxia telangiectasia; Chromosomal fragility; Immune deficiency; Syndrome
• ISSN: 0009-9104; 1365-2249

The primary IgG, IgM and IgA antibody responses to Helix pommatia haemocyanin (HPH) were defective in patients with ataxia telangiectasia (AT) and Nijmegen breakage syndrome (NBS). The results in patients with Bloom's syndrome (BS) were heterogeneous, but all showed abnormal kinetics of the IgG response. The secondary response to diphtheria, tetanus and polio vaccine was normal in patients with AT and BS, but disturbed in the patients with NBS. The abnormalities of antibody response of AT and NBS are similar, although more profound in NBS; BS is different.