Multivariate analysis of prognostic factors for curative resectable rectal cancer

Several reports have shown that prognostic factors of rectal cancer are pathological parameters such as lymph node metastases, tumour infiltration, perineural and venous infiltration, and clinical parameters such as tumour level, mobility of the tumour and number of quadrants involved. From 1979 to...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of surgical oncology Vol. 15; no. 2; p. 93
Main Authors:	Domergue, J, Rouanet, P, Daures, J P, Dubois, J B, Joyeux, H, Solassol, C, Pujol, H
Format:	Journal Article
Language:	English
Published:	England 01-04-1989
Subjects:	Adult Aged Combined Modality Therapy Female Humans Lymphatic Metastasis Male Middle Aged Neoplasm Recurrence, Local Preoperative Care Prognosis Prospective Studies Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - therapy
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Several reports have shown that prognostic factors of rectal cancer are pathological parameters such as lymph node metastases, tumour infiltration, perineural and venous infiltration, and clinical parameters such as tumour level, mobility of the tumour and number of quadrants involved. From 1979 to 1983, 208 patients were treated curatively for rectal cancer in Montpellier Cancer Institute. A multivariate analysis was done to evaluate prognostic factors of our population. Prognosis was influenced by lymph node metastases, preoperative radiotherapy, tumour infiltration and histological type. The role of preoperative radiotherapy in local control and in survival appeared highly significant. Our results confirm the importance of external beam irradiation in local recurrence and in survival as shown randomly in the EORTC prospective trial. The growing trend in sphincter-saving surgery should be associated with preoperative radiotherapy.
ISSN:	0748-7983