Atrial natriuretic factor in neonatal hypoxic-ischemic encephalopathy

The influence of perinatal asphyxia in the secretion of atrial natriuretic factor (ANF) during the first 6 days of life, and its renal consequences are discussed. Comparison between 20 healthy term neonates and 19 with first--or second--degree hypoxic-ischemic encephalopathy (HIE) is made. Daily con...

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Bibliographic Details
Published in:	Journal of perinatal medicine Vol. 21; no. 2; p. 169
Main Authors:	Carbonell, X, Figueras, J, Salvia, M D, Esque, M T, Delgado, M P, Jimenez, R
Format:	Journal Article
Language:	English
Published:	Germany 1993
Subjects:	Asphyxia Neonatorum - blood Asphyxia Neonatorum - complications Atrial Natriuretic Factor - blood Brain Damage, Chronic - blood Brain Damage, Chronic - etiology Humans Infant, Newborn
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Summary:	The influence of perinatal asphyxia in the secretion of atrial natriuretic factor (ANF) during the first 6 days of life, and its renal consequences are discussed. Comparison between 20 healthy term neonates and 19 with first--or second--degree hypoxic-ischemic encephalopathy (HIE) is made. Daily controls were performed on clinical and neurological examinations and administration of sodium and fluids. On the first and sixth days of life, 24 hours urine collection, natremia, natriuresis, fractionated excretion of sodium and creatinine clearance were determined. The ANF was performed at 1, 2, 3 and 6 days old, by R.I.A. The full term newborns with HIE showed a peak in ANF values on day two, as does the control group, thereafter maintaining higher levels, with a significant difference on day three and six. No correlation could be found between the ANF levels and the renal variables analyzed.
ISSN:	0300-5577