Dementia and antipsychotic drugs

Introduced in the 1950s, antipsychotic agents have been found to improve symptomatology and function in young and middle-aged psychotic schizophrenics. Three decades of research, however, have not made clear these agents' usefulness in demented elderly patients. A review of placebo-controlled s...

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Bibliographic Details
Published in:	The journal of clinical psychiatry Vol. 48; no. 5; pp. 16 - 18
Main Authors:	RASKIND, M. A, RISSE, S. C, LAMPE, T. H
Format:	Journal Article
Language:	English
Published:	Memphis, TN Physicians Postgraduate Press 01-05-1987
Subjects:	Aged Alzheimer Disease - drug therapy Alzheimer Disease - psychology Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Biological and medical sciences Clinical Trials as Topic Cognition Disorders - chemically induced Dementia - drug therapy Dementia - psychology Female Humans Male Medical sciences Miscellaneous Neuropharmacology Pharmacology. Drug treatments Recurrence Thioridazine - adverse effects Thioridazine - therapeutic use Human Chemotherapy Placebo Antipsychotic Controlled therapeutic trial Elderly Dementia
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Summary:	Introduced in the 1950s, antipsychotic agents have been found to improve symptomatology and function in young and middle-aged psychotic schizophrenics. Three decades of research, however, have not made clear these agents' usefulness in demented elderly patients. A review of placebo-controlled studies suggests a definite but limited role for antipsychotic medication in behaviorally disturbed elderly dementia patients with agitated behavior. Studies also suggest that cognitive function needs careful monitoring when these drugs are prescribed to treat behavioral symptoms of dementia.
ISSN:	0160-6689 1555-2101