Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]- benzothiazolidine derivatives as a potential gastric H+/K+-ATPase inhibitor

A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/K(+)-ATPase. Compound 4d exhibited potent in vitro inhibitory activity.

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 8; no. 14; pp. 1909 - 1912
Main Authors:	YOON, S.-H, SEUNGKI SEO, YOUNGHEE LEE, SUNGKWAN HWANG, DONG YEON KIM
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier 21-07-1998
Subjects:	Animals Biological and medical sciences Digestive system Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology In Vitro Techniques Medical sciences Pharmacology. Drug treatments Proton Pump Inhibitors Rats Stomach - enzymology Thiazoles - chemical synthesis Thiazoles - pharmacology Sulfur nitrogen heterocycle Enzyme H Enzyme inhibitor Antiulcer agent K Benzothiazole derivatives In vitro Structure activity relation Antisecretory agent Bicyclic compound Hydrolases exchanging ATPase Aromatic compound Chemical synthesis
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