Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]- benzothiazolidine derivatives as a potential gastric H+/K+-ATPase inhibitor

A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/K(+)-ATPase. Compound 4d exhibited potent in vitro inhibitory activity.

Saved in:

Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 8; no. 14; pp. 1909 - 1912
Main Authors:	YOON, S.-H, SEUNGKI SEO, YOUNGHEE LEE, SUNGKWAN HWANG, DONG YEON KIM
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier 21-07-1998
Subjects:	Animals Biological and medical sciences Digestive system Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology In Vitro Techniques Medical sciences Pharmacology. Drug treatments Proton Pump Inhibitors Rats Stomach - enzymology Thiazoles - chemical synthesis Thiazoles - pharmacology Sulfur nitrogen heterocycle Enzyme H Enzyme inhibitor Antiulcer agent K Benzothiazole derivatives In vitro Structure activity relation Antisecretory agent Bicyclic compound Hydrolases exchanging ATPase Aromatic compound Chemical synthesis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/K(+)-ATPase. Compound 4d exhibited potent in vitro inhibitory activity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(98)00334-5