Antinociceptive properties of N-aryl-glutaramic acids and N-aryl-glutarimides

This study describes the antinociceptive activity of some N-aryl-glutaramic acids and N-aryl-glutarimides in writhing and formalin tests, two classical models of pain in mice. These compounds show high activity, being more active than acetyl salycilic acid, acetaminophen and indomethacin, used as st...

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Bibliographic Details
Published in:	Pharmazie Vol. 55; no. 12; p. 942
Main Authors:	Stiz, D S, Souza, M M, Golin, V, Neto, R A, Corrêa, R, Nunes, R J, Yunes, R A, Cechinel-Filho, V
Format:	Journal Article
Language:	English
Published:	Germany 01-12-2000
Subjects:	Acetic Acid Analgesics - chemical synthesis Analgesics - pharmacology Aspirin - pharmacology Chromatography, Thin Layer Formaldehyde Glutamic Acid - analogs & derivatives Glutamic Acid - chemical synthesis Glutamic Acid - pharmacology Humans Indomethacin - pharmacology Magnetic Resonance Spectroscopy Muscle Contraction - drug effects Pain - chemically induced Pain - prevention & control Pain Measurement - drug effects Piperidones - chemical synthesis Piperidones - pharmacology Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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Summary:	This study describes the antinociceptive activity of some N-aryl-glutaramic acids and N-aryl-glutarimides in writhing and formalin tests, two classical models of pain in mice. These compounds show high activity, being more active than acetyl salycilic acid, acetaminophen and indomethacin, used as standard drugs for comparison. The introduction of different substituent groups in the aromatic ring caused a significant change in activity. The results obtained here are promising from a pharmacological point of view, since these simple compounds might be used as models to obtain new and potent analgesic drugs.
ISSN:	0031-7144