Determination of haloperidol and hydroxy haloperidol in human plasma by high performance liquid chromatography

Determination of haloperidol and hydroxy haloperidol in human plasma by high performance liquid chromatography

A method has been developed for the separation and measurement of haloperidol and hydroxy haloperidol in human plasma through high performance liquid chromatography. The method uses chlorohaloperidol as an internal standard and provides a limit of detection of about 0.7 nmol/l for haloperidol and 0....

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Bibliographic Details
Published in:Annales de biologie clinique (Paris) Vol. 48; no. 7; p. 455
Main Authors: Pommery, J, Foulon, O, Morineau, G, Lhermitte, M, Levron, J C, Erb, F
Format: Journal Article
Language:English
Published: France 1990
Subjects:
Chromatography, High Pressure Liquid
Haloperidol - analogs & derivatives
Haloperidol - blood
Humans
Hydroxylation
Radioimmunoassay
Reference Values
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Summary:A method has been developed for the separation and measurement of haloperidol and hydroxy haloperidol in human plasma through high performance liquid chromatography. The method uses chlorohaloperidol as an internal standard and provides a limit of detection of about 0.7 nmol/l for haloperidol and 0.67 nmol/l for hydroxy haloperidol. HPLC and RIA radioimmunoassay methods are compared.
ISSN:0003-3898