Pharmacological properties of a new fluoroquinolone on the central nervous system in rodents

• Published in: Arzneimittel-Forschung Vol. 43; no. 1; p. 56
• Main Authors: Guiol, C, Ledoussal, C, Surgé, J M
• Format: Journal Article
• Language: English
• Published: Germany 01-01-1993
• Subjects: Animals; Anti-Infective Agents - pharmacology; Behavior, Animal - drug effects; Bicuculline - antagonists & inhibitors; Body Temperature - drug effects; Central Nervous System - drug effects; Drug Interactions; Female; Fluoroquinolones; Male; Mice; Motor Activity - drug effects; Naphthyridines - pharmacology; Pentylenetetrazole; Phenylbutyrates - pharmacology; Postural Balance - drug effects; Rats; Rats, Sprague-Dawley; Seizures - chemically induced
• ISSN: 0004-4172

The pharmacological effects of the novel fluoroquinolone 7-(1R,4R-2,5-diazebicyclo[2.2.1]heptan-2-yl)-1-(1,1-dimethyl )ethyl-6-fluoro - 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (BMY-40062, CAS 116143-32-9) on central nervous system were investigated in mice and rats, in comparison in some cases with those of reference quinolones. BMY-40062 showed no effect on general behavior, spontaneous activity, body temperature and neuromuscular coordination in rats at the doses of 1000 and 250 mg/kg. None of the quinolones tested including BMY-40062 modified the seizures induced by bicuculline, a specific GABA A antagonist. BMY-40062 and ciprofloxacin did not consistently influence the pentetrazol-induced convulsions. On the contrary, pefloxacin exhibited a marked convulsivant activity. In the fenbufen (non-steroidal anti-inflammatory drug)-induced seizure model, BMY-40062 showed no effect. Enoxacin, norfloxacin followed by ciprofloxacin elicited a convulsivant effect in presence of fenbufen. Under these experimental conditions, BMY-40062 had no effect on the central nervous system compared to the other tested quinolones in rodents.