Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice

• Published in: Behavior genetics Vol. 22; no. 6; pp. 655 - 663
• Main Authors: CAPELESS, C. G, WHITNEY, G, AZEN, E. A
• Format: Journal Article
• Language: English
• Published: New York, NY Springer 01-11-1992
• Subjects: Animals; Biological and medical sciences; Chromosome Mapping; Classical genetics, quantitative genetics, hybrids; Crosses, Genetic; Female; Fundamental and applied biological sciences. Psychology; Genetic Linkage - genetics; Genetic Markers - genetics; Genetics of eukaryotes. Biological and molecular evolution; Male; Mice; Mice, Inbred Strains - genetics; Models, Genetic; Phenotype; Recombination, Genetic - genetics; Sucrose - analogs & derivatives; Taste - genetics; Taste Threshold - physiology; Vertebrata; Genetic mapping; Vertebrata; Mammalia; Sucrose; Mouse; Gustation; Rodentia; Bitter taste; Chromosome 6; Behavior
• ISSN: 0001-8244; 1573-3297
• DOI: 10.1007/BF01066636

Strain distribution patterns among recombinant inbred strains suggested that a locus influencing taste sensitivity to sucrose octaacetate was on chromosome 6. A location for Soa was established by linkage analysis of behavioral and electrophoretic data from outbred and congenic strains and from test-cross progeny. Haplotyping of 41 outbred CFW-Cr animals with a cDNA probe showed perfect cosegregation of Soa and Prp, a gene for salivary proline-rich proteins. Five of twelve B6.SW-Soaa strains were found to retain Ldr-1, lactate dehydrogenase regulator-1, on chromosome 6 as an allelic passenger from the SWR/J donor strain (source of the Soaa Taster allele). Centimorgan distance was estimated using the ABP/Le linkage-testing strain (non-Taster, Soab) and the SWR/J strain (Taster, Soaa) in a testcross breeding system. The data are consistent with a position for the Soa locus on mouse chromosome 6, 62 cM from the centromere.