In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes

Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors. The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concen...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 133; no. 6; pp. 614 - 616
Main Authors:	Kazakova, T B, Barabanova, S V, Khavinson, V Kh, Glushikhina, M S, Parkhomenko, E P, Malinin, V V, Korneva, E A
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-06-2002
Subjects:	Animals Cells, Cultured Dipeptides - pharmacology Dose-Response Relationship, Drug Gene Expression - drug effects Interleukin-2 - genetics Mice Mice, Inbred CBA Oligopeptides - pharmacology Peptides - chemistry Peptides - pharmacology Spleen - cytology Spleen - drug effects Time Factors
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Summary:	Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors. The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concentration, and duration of treatment with the peptides. Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1020210615148