Novel antifungal agents which inhibit lanosterol 14α-demethylase in Candida albicans CCH442
We have identified four non-azole inhibitors of lanosterol 14 alpha -demethylase in Candida albicans CCH442. The most potent compound, A-39806, had IC sub(50) values for ergosterol inhibition of 0.9 mu M (0.3 mg/L) and 1.9 mu M (0.6 mg/L) in whole cell and cell-free extract assays, respectively. A-3...
Saved in:
| Published in: | Journal of antimicrobial chemotherapy Vol. 39; no. 2; pp. 261 - 264 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford
Oxford University Press
01-02-1997
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | We have identified four non-azole inhibitors of lanosterol 14 alpha -demethylase in Candida albicans CCH442. The most potent compound, A-39806, had IC sub(50) values for ergosterol inhibition of 0.9 mu M (0.3 mg/L) and 1.9 mu M (0.6 mg/L) in whole cell and cell-free extract assays, respectively. A-39806 demonstrated broad in-vitro antifungal activity against several Candida species as well as against Cryptococcus albidus and Aspergillus niger. In-vitro antifungal activity was also demonstrated against a fluconazole-resistant clinical isolate of C. albicans. |
|---|---|
| AbstractList | We have identified four non-azole inhibitors of lanosterol 14 alpha -demethylase in Candida albicans CCH442. The most potent compound, A-39806, had IC sub(50) values for ergosterol inhibition of 0.9 mu M (0.3 mg/L) and 1.9 mu M (0.6 mg/L) in whole cell and cell-free extract assays, respectively. A-39806 demonstrated broad in-vitro antifungal activity against several Candida species as well as against Cryptococcus albidus and Aspergillus niger. In-vitro antifungal activity was also demonstrated against a fluconazole-resistant clinical isolate of C. albicans. |
| Author | GOLDMAN, R. C ZAKULA, D CAPOBIANCO, J. O |
| Author_xml | – sequence: 1 givenname: D surname: ZAKULA fullname: ZAKULA, D organization: Anti-infective Research Division, Abbott Laboratories, One Abbott Park Road, Abbott Park, IL 60064-3500, United States – sequence: 2 givenname: J. O surname: CAPOBIANCO fullname: CAPOBIANCO, J. O organization: Anti-infective Research Division, Abbott Laboratories, One Abbott Park Road, Abbott Park, IL 60064-3500, United States – sequence: 3 givenname: R. C surname: GOLDMAN fullname: GOLDMAN, R. C organization: Anti-infective Research Division, Abbott Laboratories, One Abbott Park Road, Abbott Park, IL 60064-3500, United States |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2602115$$DView record in Pascal Francis |
| BookMark | eNotzktOwzAYBGALFYm2sOMAXiB2aX8_4sZLFPGSKtjADin67diNq9QpcQrqsbgIZyISXc0sPo1mRiaxi46QawYLBlost2iXQi_4git2RqZMKsg4aDYhUxCQZyuZiwsyS2kLACpXxZR8vHRfrqUYh-APcYNj3bg4JPrdBNvQEJtgwkBbjF0aXN-1lMnfn6x2Ozc0xxaTGw0tMdahRoqtCRZjomX5JCW_JOce2-SuTjkn7w_3b-VTtn59fC7v1tmeMzFkZmUgd6CVV9pKK4CtPNcKsK7H21YzyY0sXG08otGFL1gBtXROeuFWYLyYk9v_3X3ffR5cGqpdSNa142vXHVLFFHDNBRvhzQlistj6HqMNqdr3YYf9seKjYywXf0WCZRY |
| CODEN | JACHDX |
| ContentType | Journal Article |
| Copyright | 1997 INIST-CNRS |
| Copyright_xml | – notice: 1997 INIST-CNRS |
| DBID | IQODW 7T7 8FD C1K FR3 M7N P64 |
| DOI | 10.1093/jac/39.2.261 |
| DatabaseName | Pascal-Francis Industrial and Applied Microbiology Abstracts (Microbiology A) Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts |
| DatabaseTitle | Engineering Research Database Technology Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management |
| DatabaseTitleList | Engineering Research Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1460-2091 |
| EndPage | 264 |
| ExternalDocumentID | 2602115 |
| GroupedDBID | --- -E4 .2P .GJ .I3 .XZ .ZR 0R~ 18M 1TH 29J 2WC 3O- 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 6.Y 70D AABJS AABMN AABZA AACZT AAESY AAIYJ AAJKP AAJQQ AAMVS AANRK AAOGV AAPGJ AAPNW AAPQZ AAPXW AAUQX AAVAP AAWDT AAWTL ABEUO ABIXL ABKDP ABLJU ABNKS ABPTD ABPTK ABQLI ABQTQ ABSAR ABSMQ ABWST ABZBJ ACCCW ACFRR ACGFO ACGFS ACIMA ACIWK ACPQN ACPRK ACUFI ACUTJ ACUTO ACYHN ADBBV ADEIU ADEYI ADEZT ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADORX ADQLU ADRIX ADRTK ADVEK ADYVW ADZXQ AEGPL AEJOX AEKPW AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFNX AFFZL AFIYH AFOFC AFRAH AFXAL AFXEN AFYAG AGINJ AGKEF AGKRT AGQXC AGSYK AGUTN AHMBA AHXPO AI. AIAGR AIJHB AIKOY AIMBJ AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APJGH APWMN AQDSO AQKUS ASMCH ASPBG ATTQO AVWKF AWCFO AXUDD AZFZN AZQFJ BAWUL BAYMD BCRHZ BEYMZ BGYMP BHONS BTRTY BVRKM BYORX BZKNY C45 CAG CASEJ CDBKE COF CS3 CZ4 DAKXR DIK DILTD DPORF DPPUQ DU5 D~K E3Z EBS ECGQY EE~ EIHJH EJD EMOBN ENERS F5P F9B FECEO FEDTE FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HH5 HW0 HZ~ IOX IQODW J21 J5H KAQDR KBUDW KOP KQ8 KSI KSN L7B M-Z M49 MBLQV MHKGH ML0 N9A NGC NOMLY NOYVH NTWIH NU- NVLIB O0~ O9- OAUYM OAWHX OBFPC OBS OCZFY ODMLO OJQWA OK1 OPAEJ OVD OWPYF O~Y P2P PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RHF RNI ROL ROX ROZ RUSNO RW1 RXO RZF RZO TCURE TEORI TJX TMA TR2 UCJ VH1 W8F WOQ X7H Y6R YAYTL YKOAZ YXANX ZGI ZKX ZXP ~91 ~A~ 7T7 8FD AARHZ AAUAY ABJNI ABNHQ ABQNK ABXVV ADQBN ATGXG C1K FR3 HVGLF JXSIZ M7N OJZSN P64 |
| ID | FETCH-LOGICAL-p213t-b7b05e096f69c4c3017f2960add030c9142b48edbfaab98f8180d4ee4f3e70bf3 |
| ISSN | 0305-7453 |
| IngestDate | Fri Oct 25 05:04:36 EDT 2024 Sun Oct 29 17:08:30 EDT 2023 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Fungi Candida albicans Antifungal agent Sensitivity resistance Enzyme Enzyme inhibitor Fungi Imperfecti In vitro Clinical isolate Thallophyta |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-p213t-b7b05e096f69c4c3017f2960add030c9142b48edbfaab98f8180d4ee4f3e70bf3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PQID | 16029231 |
| PQPubID | 23462 |
| PageCount | 4 |
| ParticipantIDs | proquest_miscellaneous_16029231 pascalfrancis_primary_2602115 |
| PublicationCentury | 1900 |
| PublicationDate | 1997-02-01 |
| PublicationDateYYYYMMDD | 1997-02-01 |
| PublicationDate_xml | – month: 02 year: 1997 text: 1997-02-01 day: 01 |
| PublicationDecade | 1990 |
| PublicationPlace | Oxford |
| PublicationPlace_xml | – name: Oxford |
| PublicationTitle | Journal of antimicrobial chemotherapy |
| PublicationYear | 1997 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| SSID | ssj0006568 |
| Score | 1.5840089 |
| Snippet | We have identified four non-azole inhibitors of lanosterol 14 alpha -demethylase in Candida albicans CCH442. The most potent compound, A-39806, had IC sub(50)... |
| SourceID | proquest pascalfrancis |
| SourceType | Aggregation Database Index Database |
| StartPage | 261 |
| SubjectTerms | Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Aspergillus niger Biological and medical sciences Candida albicans Cryptococcus albidus Medical sciences Pharmacology. Drug treatments |
| Title | Novel antifungal agents which inhibit lanosterol 14α-demethylase in Candida albicans CCH442 |
| URI | https://search.proquest.com/docview/16029231 |
| Volume | 39 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Pb9MwFLbYkBCXCQaIMQY-oF26sCV1m_iIsk5FjG6CTJq4RI5_rBlbU5EWqf8979lO0mlIwIFDrcpK3crv67Pf8_s-E_JOCIkaJUVQDGITMBkOg2TAeQAvDsvlQHOFqYHx13hymRyP2KijEHR9_9XS0Ae2RubsP1i7HRQ64D3YHFqwOrR_ZfdJ9VMj_X9RwpJ1hUoAV47ENi1tdmNaFuUC05TI7sAi9ZD1LOG2FyiN90mvYD9tlURSZLwogRXM6CvrXpqOmROp-s12Fr_xtrSyTig5MtW3ntvV5uy_ie_LG3GnyjgV88qKnrvzn7O2Gqi6UT41-8XncZWn6sVNMXPrwMCXBDFzYsCNt3XSRR5V0brrdKLsfhWOnLb5PQfvxK-uhYQWiUbv24-tK2lPzvKTi9PTPBtdZhvkYQROCMs9jz9-alfpoaNJtr_RkyJg_EMY_bAZG2tlRQ1_F-PuObm3ZNt9SPaEbPkZpx-c5Z-SB3q2TR599iUS22T_3ImRrw5o1nHr6gO6T887mfLVMyIsUmiHFOqQQi1SqEcK7ZBCQ0YtUug6UuBB6pFCG6RQh5Tn5OJklKXjwF-4EcyjsL8Iirg4GmgIas2QSybB98cmghAX1kCYJ8lDFhUs0aowQhQ8MagToJjWzPR1fFSY_guyOatm-iWhEHUkgkfGcINnzVxIpaSREuJ_oQoZ7pC9O_Oaz524Sg7xdQRRyg5528xzDg4PT7HETFfLOg_hAYxKXv3xiV3yuIPla7K5-LHUe2SjVss3Fgu_AA-Ndfc |
| link.rule.ids | 315,782,786,27935,27936 |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+antifungal+agents+which+inhibit+lanosterol+14+alpha+-demethylase+in+Candida+albicans+CCH442&rft.jtitle=Journal+of+antimicrobial+chemotherapy&rft.au=Zakula%2C+D&rft.au=Capobianco%2C+JO&rft.au=Goldman%2C+R+C&rft.date=1997-02-01&rft.issn=0305-7453&rft.volume=39&rft.issue=2&rft.spage=261&rft.epage=264&rft_id=info:doi/10.1093%2Fjac%2F39.2.261&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0305-7453&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0305-7453&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0305-7453&client=summon |