Preventing Preterm Birth: Exploring Innovative Solutions

This review examines the complexities of preterm birth (PTB), emphasizes the pivotal role of inflammation in the pathogenesis of preterm labor, and assesses current available interventions. Antibiotics, progesterone analogs, mechanical approaches, nonsteroidal anti-inflammatory drugs, and nutritiona...

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Bibliographic Details
Published in:	Clinics in perinatology Vol. 51; no. 2; pp. 497 - 510
Main Authors:	Habelrih, Tiffany, Ferri, Béatrice, Côté, France, Sévigny, Juliane, Augustin, Thalyssa-Lyn, Sawaya, Kevin, Lubell, William D, Olson, David M, Girard, Sylvie, Chemtob, Sylvain
Format:	Journal Article
Language:	English
Published:	United States 01-06-2024
Subjects:	Female Humans Infant, Newborn Inflammation - drug therapy Inflammation - prevention & control Obstetric Labor, Premature - prevention & control Pregnancy Premature Birth - prevention & control Tocolytic Agents - therapeutic use Tocolytics Preterm birth Pathophysiology Therapeutics Neonatal outcome Preterm labor Inflammation
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Summary:	This review examines the complexities of preterm birth (PTB), emphasizes the pivotal role of inflammation in the pathogenesis of preterm labor, and assesses current available interventions. Antibiotics, progesterone analogs, mechanical approaches, nonsteroidal anti-inflammatory drugs, and nutritional supplementation demonstrate a limited efficacy. Tocolytic agents, targeting uterine activity and contractility, inadequately prevent PTB by neglecting to act on uteroplacental inflammation. Emerging therapies targeting toll-like receptors, chemokines, and interleukin receptors exhibit promise in mitigating inflammation and preventing PTB.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1557-9840
DOI:	10.1016/j.clp.2024.02.006