ANTIOXIDANTS AND ANTIFUNGAL ACTIVITIES OF SUBSTITUTED GUANIDINES AND THEIR COPPER COMPLEXES

• Published in: Acta Poloniae pharmaceutica Vol. 74; no. 2; pp. 425 - 434
• Main Authors: Ahmad, Jamil, Rehman, Wajid, Said, Muhammad, Iqbal, Zafar, Naz Gul, Shehla, Ahmad, Shakeel, Khan, Nazirullah, Bibi, Iram, Qureshi, Muhammad Tauseef
• Format: Journal Article
• Language: English
• Published: Poland 01-03-2017
• Subjects: Alternaria - drug effects; Alternaria - growth & development; Antifungal Agents - chemical synthesis; Antifungal Agents - pharmacology; Antioxidants - chemical synthesis; Antioxidants - pharmacology; Copper - chemistry; Copper - pharmacology; Disk Diffusion Antimicrobial Tests; Dose-Response Relationship, Drug; Free Radical Scavengers - chemical synthesis; Free Radical Scavengers - pharmacology; Guanidines - chemical synthesis; Guanidines - pharmacology; Iron Chelating Agents - chemical synthesis; Iron Chelating Agents - pharmacology; Reactive Oxygen Species - chemistry
• ISSN: 0001-6837

A series of guanidines and their copper (II) complexes were investigated for their radical scavenging activity including peroxyl radicals (ROO), superoxide anion (O₂), hydroxyl ('OH), and reactive hydrogen per- oxide (H₂0₂) species. Among the Cu(II) complexes, Cu-MR-9-2 shows the highest, Cu-MR-9-3, Cu-MR-9-6 less and Cu-MR-9-1 least antioxidant potential. The Cu(II) complexes show better Fea'-chelating activity than that of ligands. Among the Cu(II) complexes Cu-MR-9-2 was found to have the highest, Cu-MR-9-6 moderate, MR-9-3 less and Cu-MR-9-1 least ferric reducing capacity. The IC50 values for ligands (MR-9-1, MR-9-2, MR- 9-3, MR-9-6) were determined to be 197.53 ± 7.13, 189.07 ± 7.34, 207.98 ± 6.78 and 233.38 ±6.37 pM, which showed lower antioxidant activity than their Cu(II) complexes. The IC,o values for ascorbic acid were found to be 51.60 ± 13.18 pM. The Cu(I) metal compounds (Cu-MR-9-1,Cu-MR-9-2, Cu-MR-9-3 and Cu-MR-9-6) were detected to be the most powerful scavengers of the hydroxyl radical with IC50 up to 108.03 ± 11.34 pM, 101.41 ±12.10 pM, 90.59 ± 11.53 pM and 88.86 ± 13.16 pM, respectively.