Is there association between QRS-T angle, and hormonal and sonographic features in polycystic ovarian syndrome?

• Published in: European review for medical and pharmacological sciences Vol. 24; no. 13; p. 7372
• Main Authors: Topaloğlu, Ö, Çimci, M, Yoloğlu, S, Şahin, İ
• Format: Journal Article
• Language: English
• Published: Italy 01-07-2020
• Subjects: Action Potentials; Adolescent; Adult; Biomarkers - blood; Electrocardiography; Female; Heart Conduction System - physiopathology; Heart Rate; Hormones - blood; Humans; Ovary - diagnostic imaging; Ovary - metabolism; Ovary - physiopathology; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - diagnosis; Polycystic Ovary Syndrome - physiopathology; Predictive Value of Tests; Prognosis; Prospective Studies; Thyroid Gland - diagnostic imaging; Thyroid Gland - metabolism; Thyroid Gland - physiopathology; Ultrasonography; Young Adult
• ISSN: 2284-0729
• DOI: 10.26355/eurrev_202007_21905

Polycystic ovary syndrome (PCOS) is a complex disorder comprising ovulatory dysfunction, hyperandrogenism, and polycystic ovaries (PCO). Several studies have used electrocardiography (ECG) to assess PCOS patients. We aimed to analyze the associations among QRS-T angle, hormonal parameters, and ovarian and thyroid sonography in PCOS.
Adult females with PCOS, but without comorbid illness, were included in our study. Demographic and clinical features (body mass index, Ferriman-Gallwey score, phenotype) were analyzed, as well as laboratory test results. Based on standard 12-lead ECGs, frontal plane QRS-T angles were calculated, defined as the angle between the mean QRS and the mean T vector, and verified with automatic instrument measurements. Values within the range -46 to +59° were classified as "normal", and those out of this range as "abnormal". Patients were divided into groups according to the presence of thyroid nodules, echogenicity (normal/decreased), and vascularity (normal/increased) based on thyroid sonography, and by mean ovarian volume (MOV ≥ 10/< 10 mL) or apparent PCO based on ovarian sonography.
The mean age of the 92 patients was 22.68 ± 4.58 years; 11 patients (11.9%) had abnormal QRS-T angles. Demographic, clinical, electrocardiographic, and laboratory parameters were similar between the normal and abnormal QRS-T angle groups, with the exception of MOV, which was higher in the latter group (p=0.032). Among all clinical and laboratory parameters, only MOV was a strong predictor of abnormal QRS-T angle (p=0.016).
Our study is the first to analyze the association between the QRS-T angle and hormonal and sonographic features of patients with PCOS. A small percentage of patients had abnormal QRS-T angles, and a large MOV was a strong predictor of this abnormality.