The complete picture of changing pediatric inflammatory bowel disease incidence in Spain in 25 years (1985-2009): the EXPERIENCE registry

• Published in: Journal of Crohn's and colitis Vol. 8; no. 8; pp. 763 - 769
• Main Authors: Martín-de-Carpi, J, Rodríguez, A, Ramos, E, Jiménez, S, Martínez-Gómez, M J, Medina, E, Navas-López, V M
• Format: Journal Article
• Language: English
• Published: England 01-08-2014
• Subjects: Adolescent; Age Factors; Child; Child, Preschool; Colitis, Ulcerative - epidemiology; Crohn Disease - epidemiology; Female; Humans; Incidence; Infant, Newborn; Inflammatory Bowel Diseases - epidemiology; Male; Registries; Retrospective Studies; Sex Factors; Spain - epidemiology; Spain; EXPERIENCE registry; IBD unclassified; Pediatric inflammatory bowel disease; Crohn's disease; SPIRIT registry; Incidence; Ulcerative colitis
• ISSN: 1876-4479
• DOI: 10.1016/j.crohns.2014.01.005

A growing incidence of pediatric IBD (PIBD) in southern Europe has been recently reported. The SPIRIT registry (1996-2009) confirmed these tendencies in Spain. Our aim is to obtain data from 1985 to 1995 and describe the complete picture of PIBD presentation changes in Spain in the last 25years.
A retrospective survey of incident PIBD in the period 1985-1995 was performed. Patients' data were obtained from the hospitals' databases and compared with the published data from the 1996 to 2009 period. Seventy-eight IBD reference centers took part in this survey.
Data from 495 patients were obtained: 278 CD (56.2%), 198 UC (40%), and 19 IBDU (3.8%); 51.7% were female, with higher predominance both in UC (58.6%) and in IBDU (57.9%), but not in CD (46.4%). Median (IQR) age at diagnosis was 12.9 (10.0-15.7) years, with significant differences among IBD subtypes: CD: 13.1 (10.8-16.0) vs UC: 12.4 (9.4-15.1) vs IBDU: 7.5 (3.0-13.0) (p≤0.001). These results are significantly different to the ones in the SPIRIT registry, with a higher proportion of IBDU, younger age and male predominance. The data from both periods taken together give a complete picture of a 25-year period. An annual increase of incident patients was observed, with a ten-fold increase over this period.
These data extend the epidemiological trends to a full 25-year period (1985-2009). PIBD incidence in Spain has experienced a sixteen-fold increase. The IBD subtype, localization of the affected segment, age- and sex distribution observed are in accordance with our previously published ones of 1996-2009.