Interrelationship between polymorphic markers of methylenetetrahydrofolate reductase gene and development of acute disturbance of brain circulation in families of patients with atrial fibrillation

• Published in: Kardiologiia Vol. 53; no. 3; p. 55
• Main Authors: Aksiutina, N V, Nikulina, S Iu, Shul'man, V A, Nazarov, B V, Dudkina, K V, Bezruk, G V, Balog, A I, Kotlovskiĭ, Iu V, Osedko, O Ia, Kovaleva, O A, Shteĭnerdt, S V, Chernova, A A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2013
• Subjects: Adult; Aged; Atrial Fibrillation - complications; Atrial Fibrillation - genetics; Cerebrovascular Circulation - genetics; Female; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Pedigree; Polymorphism, Single Nucleotide; Stroke - etiology; Stroke - genetics
• ISSN: 0022-9040

In the present work we for the first time on the clinic-genetic material revealed genetic predictors of development of acute disturbance of brain circulation (ADBC) in families of patients with atrial fibrillation (AF) namely polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene. Genotype CC was significantly more often found among patients with AF and ADBC compared with controls (58.1 and 35.2%, respectively, p=0.02) as well as in relatives of probands compared with the control group (59.3 and 35.2%, respectively, p=0.008). With this in relatives with revealed paroxysmal AF and ADBC we also noted presence of CC genotype. Taking into consideration the relationship obtained between polymorphysms of MTHFR gene and AF it was possible to assume that polymorphic marker CC appeared to be a predictor of ADBC in these families.