Molecular analysis of two novel Neisseria gonorrhoeae virulent components: the macrophage infectivity potentiator and the outer membrane protein A

• Published in: The New microbiologica Vol. 33; no. 2; pp. 167 - 170
• Main Authors: Starnino, Stefania, Leuzzi, Rosanna, Ghisetti, Valeria, De Francesco, Maria Antonia, Cusini, Marco, Impara, Giampaolo, Galluppi, Emma, Pizza, Mariagrazia, Stefanelli, Paola
• Format: Journal Article
• Language: English
• Published: Italy 01-04-2010
• Subjects: Amino Acid Sequence; Bacterial Outer Membrane Proteins - chemistry; Bacterial Outer Membrane Proteins - genetics; Bacterial Outer Membrane Proteins - immunology; Bacterial Outer Membrane Proteins - metabolism; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - immunology; Bacterial Proteins - metabolism; Gonorrhea - immunology; Gonorrhea - microbiology; Humans; Macrophages - microbiology; Molecular Sequence Data; Neisseria gonorrhoeae - genetics; Neisseria gonorrhoeae - immunology; Neisseria gonorrhoeae - metabolism; Neisseria gonorrhoeae - pathogenicity; Recombinant Proteins - genetics; Recombinant Proteins - immunology; Recombinant Proteins - metabolism; Sequence Analysis, DNA; Urethritis - immunology; Urethritis - microbiology; Virulence Factors - chemistry; Virulence Factors - genetics; Virulence Factors - immunology; Virulence Factors - metabolism
• ISSN: 1121-7138

Molecular analyses of mip and ompA genes were performed on 20 Neisseria gonorrhoeae isolates. The genes were present with a high degree of conservation in all strains. Sera from patients with urethritis or disseminated gonococcal infections were able to recognize the purified Neisseria gonorrhoeae macrophage infectivity potentiator (Ng-MIP) and Neisseria gonorrhoeae outer membrane protein A (Ng-OmpA).