Activity of Ertapenem and Ceftriaxone in the eradication of Salmonella in a model of experimental peritonitis in mice

• Published in: Revista española de quimioterapia Vol. 22; no. 3; pp. 135 - 138
• Main Authors: Lozano, F S, García, M I, García, E, González, B, García, M B, García, F J, García, J E
• Format: Journal Article
• Language: English
• Published: Spain 01-09-2009
• Subjects: Animals; Anti-Bacterial Agents - therapeutic use; beta-Lactams - therapeutic use; Ceftriaxone - therapeutic use; Dose-Response Relationship, Drug; Male; Mice; Peritonitis - drug therapy; Peritonitis - microbiology; Peritonitis - mortality; Salmonella enterica - drug effects; Salmonella Infections - drug therapy; Salmonella Infections - microbiology; Salmonella Infections - mortality
• ISSN: 0214-3429

Since the beginning of the 1990s, the prevalence of isolates of non-typhoidal Salmonella species resistant to antimicrobial agents, including those commonly used for the treatment of Salmonella infections such as fluoroquinolones, trimethoprim-sulfamethoxazole or beta-lactams, has increased substantially. Infections caused by multidrug-resistant strains of non-typhoidal Salmonella are now frequently encountered. In order to consider an appropriate role of Ertapenem in Salmonella-due intraabdominal infections, in the present study we compare the efficacy of Ertapenem versus that of Ceftriaxone in a mouse peritonitis model. Bacteriological eradication from blood, liver and mesenteric lymph nodes was observed after 5 and 7 days of treatment in all infected mice receiving ceftriaxone. Although both antimicrobial agents -Ertapenem and Ceftriaxone- were observed to be effective in reducing mortality in inoculated mice, our data suggests a reduced efficacy of Ertapenem in the bacteriological eradication of Salmonella enterica serotype Typhimurium in a mouse peritonitis model.