Mechanism of action of Nizhne-Ivkinskaya 2K sulfate-calcium mineral water in combined treatment of acid-dependent gastrointestinal diseases

• Published in: Terapevtic̆eskii arhiv Vol. 80; no. 1; p. 23
• Main Authors: Guliaev, P V, Pomaskina, T V, Kunshin, A A, Chervotkina, L A, Guliaeva, S F, Tsirkin, V I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2008
• Subjects: Calcium Sulfate - analysis; Female; Gastric Acid - metabolism; Gastric Acidity Determination; Gastrointestinal Diseases - diet therapy; Gastrointestinal Diseases - metabolism; Humans; Male; Middle Aged; Mineral Waters - analysis; Mineral Waters - therapeutic use; Russia; Treatment Outcome; Russia
• ISSN: 0040-3660

To study efficacy of drinking mineral water (MW) nizhne-ivkinskaya 2K in combined sanatorium treatment of gastrointestinal acid-dependent diseases (ADD) and the role of endogenic modulators of M-cholinoreactivity in pathogenesis of ADD.
General condition of the patients, gastric pH and peristalsis (computer system Gastrolog-M), gastric and gall bladder motility (Aloka SSD 1100), hepatic function (by bilirubin and AST and ALT activity), lipid spectrum (including LDLP and HDLP) and M-cholinomodulating activity of the blood serum (by biomethod) were examined in 134 subjects: 20 healthy subjects and 114 patients with ADD.
In ADD, gastric juice acidity is high, gastric and gall bladder motility is low, total cholesterol and LDLP cholesterol are elevated, M-cholinoblocking activity of the blood serum is reduced 10-fold. Intake of nizhne-ivkinskaya 2K mineral water for 21 days improved the patients' health, normalized gastric pH, motility of the stomach and gall bladder, reduced content of LDLP and restored M-cholinoblocking serum activity.
ADD development is thought to result from excessive vagus effect due to elevated blood level of lysophosphatidylcholine (LPC). In certain concentrations it can enhance efficacy of M-cholinergic impacts on gastric cells. Reduction of LDLP content due to intake of the mineral water leads to normalization of M-cholinergic impacts on gastric cells.