Induction of apoptosis in human gastric cancer by sodium butyrate

Novel therapeutic agents are needed in the adjuvant treatment of gastric cancer. The differentiating agent sodium butyrate (NaBT) inhibits the growth of colon cancer cells; its effects on gastric cancers are not known. The purpose of our study was to characterize the effects of NaBT on human gastric...

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Bibliographic Details
Published in:	Anticancer research Vol. 20; no. 2A; p. 779
Main Authors:	Litvak, D A, Hwang, K O, Evers, B M, Townsend, Jr, C M
Format:	Journal Article
Language:	English
Published:	Greece 01-03-2000
Subjects:	Apoptosis - drug effects Apoptosis Regulatory Proteins bcl-2 Homologous Antagonist-Killer Protein bcl-2-Associated X Protein Butyrates - toxicity Cell Cycle Proteins Cell Death - drug effects Cell Division - drug effects Cell Survival - drug effects Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclins - genetics Gene Expression Regulation, Neoplastic - drug effects Genes, bcl-2 Genes, p53 Humans Membrane Proteins - genetics Microtubule-Associated Proteins - genetics Proteins - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 Stomach Neoplasms Tumor Cells, Cultured Tumor Suppressor Proteins
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