Processing of proenkephalin-A in bovine chromaffin cells. Identification of natural derived fragments by N-terminal sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry

A large variety of proenkephalin-A-derived peptides (PEAPs) are present in bovine adrenal medulla secretory granules that are cosecreted with catecholamines upon stimulation of chromaffin cells. In the present paper, after reverse phase high performance liquid chromatography of intragranular soluble...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 275; no. 49; pp. 38355 - 38362
Main Authors:	Goumon, Y, Lugardon, K, Gadroy, P, Strub, J M, Welters, I D, Stefano, G B, Aunis, D, Metz-Boutigue, M H
Format:	Journal Article
Language:	English
Published:	United States 08-12-2000
Subjects:	Adrenal Medulla - cytology Adrenal Medulla - metabolism Amino Acid Sequence Animals Cattle Cells, Cultured Chromaffin Cells - metabolism Cricetinae Cytoplasmic Granules - metabolism Enkephalins - chemistry Enkephalins - metabolism Humans Mesocricetus Mice Molecular Sequence Data Peptide Fragments - chemistry Protein Precursors - chemistry Protein Precursors - metabolism Protein Processing, Post-Translational Sequence Alignment Sequence Homology, Amino Acid Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Xenopus laevis
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