The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma

The gene of phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) has been implicated as an oncogene in ovarian cancer [L. Shayesteh et al., Nat. Genet., 21: 99-102, 1999]. In this study, we examined the expression of PIK3CA mRNA and its p110alpha protein product in human ovarian carcinoma...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 63; no. 14; pp. 4225 - 4231
Main Authors:	Zhang, Lin, Yang, Nuo, Katsaros, Dionyssios, Huang, Wei, Park, Jin-Wan, Fracchioli, Stefano, Vezzani, Cristina, Rigault de la Longrais, Irene A, Yao, Weijia, Rubin, Stephen C, Coukos, George
Format:	Journal Article
Language:	English
Published:	United States 15-07-2003
Subjects:	Apoptosis - physiology Catalytic Domain Cell Division - physiology Chromones - pharmacology Endothelial Growth Factors - biosynthesis Endothelial Growth Factors - genetics Enzyme Inhibitors - pharmacology Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Hypoxia-Inducible Factor 1, alpha Subunit Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - genetics Lymphokines - biosynthesis Lymphokines - genetics Morpholines - pharmacology Neovascularization, Pathologic - enzymology Neovascularization, Pathologic - genetics Ovarian Neoplasms - blood supply Ovarian Neoplasms - enzymology Ovarian Neoplasms - genetics Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - biosynthesis Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics Transcription Factors - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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