A novel plasmin-inhibitor inhibits the growth of human tumor xenografts and decreases metastasis number

The novel plasmin inhibitor YO-2, which also exerts an apoptosis-inducing effect on various human tumor cell cultures, was examined regarding its tumor growth inhibitory and antimetastatic action. The tumor growth inhibitory effect of YO-2 was studied using HT-29 human colon carcinoma, HT-18 human m...

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Bibliographic Details
Published in:	In vivo (Athens) Vol. 16; no. 5; p. 281
Main Authors:	Szende, Béla, Okada, Yoshio, Tsuda, Yuko, Horvath, Aniko, Bökönyi, Gyöngyi, Okamoto, Shosuke, Wanaka, Keiko, Kéri, György
Format:	Journal Article
Language:	English
Published:	Greece 01-09-2002
Subjects:	Animals Antineoplastic Agents - pharmacology Dipeptides - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Fibrinolysin - antagonists & inhibitors Humans Immunocompromised Host Lung Neoplasms - prevention & control Lung Neoplasms - secondary Male Melanoma, Experimental - prevention & control Melanoma, Experimental - secondary Mice Mice, Inbred C57BL Mice, Inbred CBA Neoplasm Metastasis - prevention & control Neoplasm Transplantation Neoplasms, Experimental - prevention & control Neoplasms, Experimental - secondary Tumor Cells, Cultured Xenograft Model Antitumor Assays
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Summary:	The novel plasmin inhibitor YO-2, which also exerts an apoptosis-inducing effect on various human tumor cell cultures, was examined regarding its tumor growth inhibitory and antimetastatic action. The tumor growth inhibitory effect of YO-2 was studied using HT-29 human colon carcinoma, HT-18 human melanoma and HT-58 human B cell lymphoma inoculated as xenografts into immuno-deprived mice. Antimetastatic activity was tested on the B16 mouse melanoma muscle-lung model. YO-2 inhibited the growth of all xenografts in the range of 40-50%, when administered s.c. at a dose of 2.0 mg/kg (HT-29, HT-58) or orally at a dose of 0.4 mg/kg (HT-18). YO-2 decreased the number of lung metastasis found in mice inoculated i.m. with B16 melanoma, 4 mg/kg being the most effective. Since YO-2 is the only plasmin inhibitor having antihemorrhagic and also antitumor effect, this compound could be rationally used in combination therapy of neoplastic disease, especially when hemorrhage aggravates the course of the disease.
ISSN:	0258-851X