Malformations of angiogenesis in the low differentiated human carcinomas. immunohistochemical study

Our previous observations showed that the perivascular mesenchyma of the thin-walled vessels (capillaries) in cancers may be the source of organ-specific stem cells. We suggested that the cells forming vascular channels in altered stroma participate in the tumor development. This study was designed...

Full description

Saved in:

Bibliographic Details
Published in:	Archivum Immunologiae et Therapiae Experimentalis Vol. 49; no. 1; p. 59
Main Authors:	Zółtowska, A, St piński, J, Lewko, B, Zamorska, B, Roszkiewicz, A, Serkies, K, Kruszewski, W J
Format:	Journal Article
Language:	English
Published:	Switzerland 2001
Subjects:	Breast Neoplasms - blood supply Breast Neoplasms - immunology Breast Neoplasms - pathology Cell Differentiation Colonic Neoplasms - blood supply Colonic Neoplasms - immunology Colonic Neoplasms - pathology Factor VIII - metabolism Female Humans Immunohistochemistry Lung Neoplasms - blood supply Lung Neoplasms - immunology Lung Neoplasms - pathology Lymphatic Metastasis - immunology Lymphatic Metastasis - pathology Neoplasms - blood supply Neoplasms - immunology Neoplasms - pathology Neovascularization, Pathologic - pathology Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Our previous observations showed that the perivascular mesenchyma of the thin-walled vessels (capillaries) in cancers may be the source of organ-specific stem cells. We suggested that the cells forming vascular channels in altered stroma participate in the tumor development. This study was designed to examine the distribution of the vessels and their appearance in the breast, lung and colon cancers. Using immunohistochemical methods, we have shown that in the low differentiated tumors both CD31 and factor VIII antigens may be expressed in capillaries chiefly on the periphery of neoplastic foci. Many of these vessels were discontinuous, with interruptions or unformed tubules. Sporadically, CD31 protein and factor VIII antigens were not expressed in capillaries inside the very low differentiated cancer cases. It is difficult to assess by immunohistochemical means whether the vascular malformations are the primary or secondary phenomena in the malignancy and why these abnormalities were especially visible in some low differentiated cancers.
ISSN:	0004-069X