Haemoglobin solutions: reversibly bound oxygen and its effect upon the hypoxic heart

Haemoglobin solutions: reversibly bound oxygen and its effect upon the hypoxic heart

Stroma-free solutions of human haemoglobin modified with pyridoxal-5-phosphate, glutaraldehyde, borohydride and serum albumin were injected into the artery of an isolated rat heart perfused with Krebs-Henseleit solution under hypoxic conditions. About 70% of the oxygen transported by the modified ha...

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Bibliographic Details
Published in:Physiologia Bohemoslovaca Vol. 35; no. 3; p. 193
Main Authors: Pristoupil, T I, Kramlová, M, Fricová, V, Mosinger, B
Format: Journal Article
Language:English
Published: Czech Republic 1986
Subjects:
Animals
Blood Substitutes
Borohydrides
Chemical Phenomena
Chemistry
Glutaral
Heart - physiology
Oxyhemoglobins - metabolism
Perfusion
Pyridoxal Phosphate
Rats
Serum Albumin
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Summary:Stroma-free solutions of human haemoglobin modified with pyridoxal-5-phosphate, glutaraldehyde, borohydride and serum albumin were injected into the artery of an isolated rat heart perfused with Krebs-Henseleit solution under hypoxic conditions. About 70% of the oxygen transported by the modified haemoglobin was found to be utilized for a marked increase in the force of heart contraction. The results were in general correlation to the analysis of oxygenation curves of haemoglobin samples under study and confirmed the oxygen offloading ability.
ISSN:0369-9463