MyoD1 protein expression in alveolar soft part sarcoma as confirmatory evidence of its skeletal muscle nature

A typical case of alveolar soft part sarcoma was found to express in a strong and widespread fashion the marker MyoD1 protein. This nuclear phosphoprotein is the product of a regulatory gene that controls the commitment of a cell to myogenic lineage; it therefore provides strong and perhaps definiti...

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Bibliographic Details
Published in:	The American journal of surgical pathology Vol. 15; no. 10; p. 974
Main Authors:	Rosai, J, Dias, P, Parham, D M, Shapiro, D N, Houghton, P
Format:	Journal Article
Language:	English
Published:	United States 01-10-1991
Subjects:	Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Male Middle Aged Muscle Proteins - genetics Muscle Proteins - metabolism Muscles - pathology MyoD Protein Sarcoma - genetics Sarcoma - metabolism Sarcoma - pathology Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - metabolism Soft Tissue Neoplasms - pathology
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Summary:	A typical case of alveolar soft part sarcoma was found to express in a strong and widespread fashion the marker MyoD1 protein. This nuclear phosphoprotein is the product of a regulatory gene that controls the commitment of a cell to myogenic lineage; it therefore provides strong and perhaps definitive evidence in support of the skeletal muscle nature of this enigmatic neoplasm.
ISSN:	0147-5185
DOI:	10.1097/00000478-199110000-00008