Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1

Ageing impairs tissue repair. This defect is pronounced in skeletal muscle, whose regeneration by muscle stem cells (MuSCs) is robust in young-adult animals, but inefficient in older organisms. Despite this functional decline, old MuSCs are amenable to rejuvenation through strategies that improve th...

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Bibliographic Details
Published in:	Nature metabolism Vol. 2; no. 4; pp. 307 - 317
Main Authors:	Brett, Jamie O., Arjona, Marina, Ikeda, Mika, Quarta, Marco, de Morrée, Antoine, Egner, Ingrid M., Perandini, Luiz A., Ishak, Heather D., Goshayeshi, Armon, Benjamin, Daniel I., Both, Pieter, Rodríguez-Mateo, Cristina, Betley, Michael J., Wyss-Coray, Tony, Rando, Thomas A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-04-2020
Subjects:	13/100 631/532/2118/2439 631/532/7 692/698/1671/1668/1973 Animals Biomedical and Life Sciences Cell Separation Cell Transplantation Cyclin D1 - metabolism Flow Cytometry Letter Life Sciences Mice Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Physical Conditioning, Animal Stem Cells - cytology Stem Cells - metabolism
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