Chronic salicylate intoxication and rhabdomyolysis in a patient with scleroderma and Sjögren's syndrome

A 44-year-old woman with scleroderma and Sjögren's syndrome developed altered consciousness, acute renal failure, and rhabdomyolysis. She had no history of trauma, seizures, alcohol abuse, hyperthermia, or other possible causative factors for rhabdomyolysis. A high serum salicylate level indica...

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Bibliographic Details
Published in:	Journal of rheumatology Vol. 21; no. 2; p. 357
Main Authors:	Nawata, Y, Kagami, M, Nakajima, H, Matsumura, R, Sugiyama, T, Sueishi, M, Hirasawa, H, Iwamoto, I, Yoshida, S
Format:	Journal Article
Language:	English
Published:	Canada 01-02-1994
Subjects:	Acute Kidney Injury - etiology Acute Kidney Injury - therapy Adult Female Hemodiafiltration Humans Rhabdomyolysis - etiology Rhabdomyolysis - therapy Salicylates - adverse effects Salicylic Acid Scleroderma, Systemic - complications Sjogren's Syndrome - complications Unconsciousness - etiology
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Summary:	A 44-year-old woman with scleroderma and Sjögren's syndrome developed altered consciousness, acute renal failure, and rhabdomyolysis. She had no history of trauma, seizures, alcohol abuse, hyperthermia, or other possible causative factors for rhabdomyolysis. A high serum salicylate level indicated a diagnosis of salicylate intoxication. Medical history after recovery revealed chronic salicylate ingestion for severe headaches. This is possibly the first reported case of rhabdomyolysis caused by chronic salicylate intoxication. Continuous hemodiafiltration early in hospitalization was an effective treatment.
ISSN:	0315-162X